2-Methoxy-6-polyprenyl-1,4-benzoquinol methylase

2-Methoxy-6-polyprenyl-1,4-benzoquinol methylase (EC 2.1.1.201, ubiE (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol 5-C-methyltransferase.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol

\rightleftharpoons

S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol

This enzyme is involved in ubiquinone biosynthesis.

References

↑ Lee, P.T.; Hsu, A.Y.; Ha, H.T.; Clarke, C.F. (1997). "A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene". J. Bacteriol. 179 (5): 1748–1754. PMC 178890. PMID 9045837.
↑ Young, I.G.; McCann, L.M.; Stroobant, P.; Gibson, F. (1971). "Characterization and genetic analysis of mutant strains of Escherichia coli K-12 accumulating the biquinone precursors 2-octaprenyl-6-methoxy-1,4-benzoquinone and 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone". J. Bacteriol. 105 (3): 769–778. PMID 4323297.
↑ Dibrov, E.; Robinson, K.M.; Lemire, B.D. (1997). "The COQ5 gene encodes a yeast mitochondrial protein necessary for ubiquinone biosynthesis and the assembly of the respiratory chain". J. Biol. Chem. 272 (14): 9175–9181. doi:10.1074/jbc.272.14.9175. PMID 9083048.
↑ Barkovich, R.J.; Shtanko, A.; Shepherd, J.A.; Lee, P.T.; Myles, D.C.; Tzagoloff, A.; Clarke, C.F. (1997). "Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis". J. Biol. Chem. 272 (14): 9182–9188. doi:10.1074/jbc.272.14.9182. PMID 9083049.

External links

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: one carbon transferases (EC 2.1)

2.1.1: Methyl-

N-	Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase

O-	5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase Catechol-O-methyl transferase

Homocysteine	Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase

Other	Phosphatidyl ethanolamine methyltransferase DNMT3B Histone methyltransferase Thymidylate synthase DNA methyltransferase Thiopurine methyltransferase

2.1.2: Hydroxymethyl-,
Formyl- and Related

Hydroxymethyltransferase	Serine hydroxymethyltransferase 3-methyl-2-oxobutanoate hydroxymethyltransferase

Formyltransferase	Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase

Other	Glutamate formimidoyltransferase Aminomethyltransferase

2.1.3: Carboxy-
and Carbamoyl

Carboxy	methylmalonyl-CoA carboxytransferase

Carbamoyl	Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase 3-hydroxymethylcephem carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase

2.1.4: Amidine

Arginine:glycine amidinotransferase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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