23S rRNA pseudouridine955/2504/2580 synthase
| 23S rRNA pseudouridine955/2504/2580 synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.4.99.24 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
23S rRNA pseudouridine955/2504/2580 synthase (EC 5.4.99.24, RluC, pseudouridine synthase RluC) is an enzyme with systematic name 23S rRNA-uridine955/2504/2580 uracil mutase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- 23S rRNA uridine955/uridine2504/uridine2580 23S rRNA pseudouridine955/pseudouridine2504/pseudouridine2580
The enzyme converts uridines at position 955, 2504 and 2580 of 23S rRNA to pseudouridines.
References
- ↑ Jiang, M.; Sullivan, S.M.; Walker, A.K.; Strahler, J.R.; Andrews, P.C.; Maddock, J.R. (2007). "Identification of novel Escherichia coli ribosome-associated proteins using isobaric tags and multidimensional protein identification techniques". J. Bacteriol. 189: 3434–3444. doi:10.1128/jb.00090-07. PMID 17337586.
- ↑ Conrad, J.; Sun, D.; Englund, N.; Ofengand, J. (1998). "The rluC gene of Escherichia coli codes for a pseudouridine synthase that is solely responsible for synthesis of pseudouridine at positions 955, 2504, and 2580 in 23 S ribosomal RNA". J. Biol. Chem. 273: 18562–18566. doi:10.1074/jbc.273.29.18562. PMID 9660827.
- ↑ Corollo, D.; Blair-Johnson, M.; Conrad, J.; Fiedler, T.; Sun, D.; Wang, L.; Ofengand, J.; Fenna, R. (1999). "Crystallization and characterization of a fragment of pseudouridine synthase RluC from Escherichia coli". Acta Crystallogr. D. 55: 302–304. doi:10.1107/s090744499801021x. PMID 10089432.
- ↑ Toh, S.M.; Mankin, A.S. (2008). "An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors". J. Mol. Biol. 380: 593–597. doi:10.1016/j.jmb.2008.05.027. PMID 18554609.
External links
- 23S rRNA pseudouridine955/2504/2580 synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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