3beta(or 20alpha)-hydroxysteroid dehydrogenase

3β(or 20α)-hydroxysteroid dehydrogenase
Identifiers
EC number 1.1.1.210
CAS number 82869-26-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 3-β(or 20-α)-hydroxysteroid dehydrogenase (EC 1.1.1.210) is an enzyme that catalyzes the chemical reaction

5α-androstan-3β,17β-diol + NADP+ 17β-hydroxy-5α-androstan-3-one + NADPH + H+

This enzyme possesses the combined activities of the 3-β-hydroxysteroid dehydrogenase/Δ-5-4 isomerase and 20-α-hydroxysteroid dehydrogenase enzymes.[1]

References

  1. Sharaf MA, Sweet F (September 1982). "Dual activity at an enzyme active site: 3 beta,20 alpha-hydroxysteroid oxidoreductase from fetal blood". Biochemistry. 21 (19): 4615–20. doi:10.1021/bi00262a016. PMID 6958329.


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