ABCC13

Identifiers

ABCC13, C21orf73, PRED6, ABCC13P, ATP binding cassette subfamily C member 13 (pseudogene)

External IDs

Gene ontology
Molecular function	• ATPase activity, coupled to transmembrane movement of substances • ATP binding
Cellular component	• integral component of membrane • membrane
Biological process	• transmembrane transport • transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


150000


n/a

Ensembl


ENSG00000243064


n/a

UniProt


Q9NSE7


n/a

RefSeq (mRNA)


NM_138726 NM_172024 NM_172025 NM_172026


n/a

RefSeq (protein)


n/a


n/a

Location (UCSC)

Chr 21: 14.24 – 14.36 Mb

n/a

PubMed search

^[1]

n/a

Wikidata

View/Edit Human

Putative ATP-binding cassette transporter sub-family C member 13 is a protein that in humans is encoded by the ABCC13 gene.^[2]

Function

This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described.^[2]

References

Dean M, Annilo T (2005). "Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates". Annual Review of Genomics and Human Genetics. 6: 123–42. doi:10.1146/annurev.genom.6.080604.162122. PMID 16124856.
Annilo T, Dean M (Jul 2004). "Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages". Genomics. 84 (1): 34–46. doi:10.1016/j.ygeno.2004.02.010. PMID 15203202.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
Brun ME, Ruault M, Ventura M, Roizès G, De Sario A (Jul 2003). "Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms". Gene. 312: 41–50. doi:10.1016/S0378-1119(03)00530-4. PMID 12909339.
Yabuuchi H, Takayanagi S, Yoshinaga K, Taniguchi N, Aburatani H, Ishikawa T (Dec 2002). "ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver". Biochemical and Biophysical Research Communications. 299 (3): 410–7. doi:10.1016/S0006-291X(02)02658-X. PMID 12445816.
Gardiner K, Slavov D, Bechtel L, Davisson M (Jun 2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis". Genomics. 79 (6): 833–43. doi:10.1006/geno.2002.6782. PMID 12036298.
Allikmets R, Gerrard B, Hutchinson A, Dean M (Oct 1996). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Human Molecular Genetics. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane proteins, carrier proteins: membrane transport proteins ABC-transporter (TC 3A1)

A	A1 A2 A3 A4 A7 A8 A12 A13

B	B1 B2-3 (B2 B3) B4 B5 B6 B7 B9 B11

C	C1 C2 C3 C4 C5 C6 C7 C8-9 (C8, C9) C10 C11 C13

D	D1 D2 D3 D4

E	E1

F	F1 F2

G	G1 G2 G4 Sterolin (G5, G8)

see also ABC transporter disorders

This article is issued from Wikipedia - version of the 5/19/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

ABCC13

Function

See also

References

Further reading