APBB3

APBB3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases APBB3, FE65L2, SRA, amyloid beta precursor protein binding family B member 3
External IDs MGI: 108404 HomoloGene: 21221 GeneCards: APBB3
Orthologs
Species Human Mouse
Entrez

10307

225372

Ensembl

ENSG00000113108

ENSMUSG00000006050

UniProt

O95704
Q96DX9

Q8R1C9

RefSeq (mRNA)

NM_146085

RefSeq (protein)

NP_666197.1

Location (UCSC) Chr 5: 140.56 – 140.59 Mb Chr 18: 36.67 – 36.68 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Amyloid beta A4 precursor protein-binding family B member 3 is a protein that in humans is encoded by the APBB3 gene.[3][4]

The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T, Sudol M (Jan 1998). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled". J Biol Chem. 272 (52): 32869–77. doi:10.1074/jbc.272.52.32869. PMID 9407065.
  4. 1 2 "Entrez Gene: APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3".

Further reading

External links


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