Alcohol sulfotransferase

Alcohol sulfotransferase is an enzyme that catalyzes the sulfate conjugation of primary and secondary alcohols including many hormones, neurotransmitters, drugs, and xenobiotic compounds.^[1]^[2]

The chemical reaction is:

an alcohol + 3'-phosphoadenylyl-sulfate

\rightleftharpoons

adenosine 3',5'-bisphosphate + an organosulfate + H+

Family members

Human genes that encode alcohol sulfotransferases include:

References

↑ Lyon ES, Jakoby WB (July 1980). "The identity of alcohol sulfotransferases with hydroxysteroid sulfotransferases". Arch. Biochem. Biophys. 202 (2): 474–81. doi:10.1016/0003-9861(80)90452-X. PMID 6935986.
↑ Lyon ES, Marcus CJ, Wang JL, Jakoby WB (1981). "Hydroxysteroid sulfotransferase". Meth. Enzymol. 77: 206–13. doi:10.1016/S0076-6879(81)77027-7. PMID 6173569.

External links

alcohol sulfotransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Metabolism: lipid metabolism – ketones/cholesterol synthesis enzymes/steroid metabolism

Mevalonate pathway

To HMG-CoA	Acetyl-Coenzyme A acetyltransferase HMG-CoA synthase (regulated step)

Ketogenesis	HMG-CoA lyase 3-hydroxybutyrate dehydrogenase Thiophorase

To Mevalonic acid	HMG-CoA reductase

To DMAPP	Mevalonate kinase Phosphomevalonate kinase Pyrophosphomevalonate decarboxylase Isopentenyl-diphosphate delta isomerase

Geranyl-	Dimethylallyltranstransferase Geranyl pyrophosphate

To cholesterol

To lanosterol	Farnesyl-diphosphate farnesyltransferase Squalene monooxygenase Lanosterol synthase

7-Dehydrocholesterol path	Lanosterol 14α-demethylase Sterol-C5-desaturase-like 7-Dehydrocholesterol reductase

Desmosterol path	24-dehydrocholesterol reductase

To Bile acids

Steroidogenesis

To pregnenolone

Side-chain cleavage

To corticosteroids

aldosterone: 18-hydroxylase

To sex hormones

To androgens	17α-hydroxylase/17,20 lyase 3β dehydrogenase 17β dehydrogenase 5α reductase 1 2

To estrogens	Aromatase

Other/ungrouped

Transferases: sulfur-containing group (EC 2.8)

2.8.1: Sulfurtransferases	Thiosulfate sulfurtransferase Rhodanese 3-mercaptopyruvate sulfurtransferase thiosulfate—thiol sulfurtransferase tRNA sulfurtransferase thiosulfate—dithiol sulfurtransferase biotin synthase cysteine desulfurase

2.8.2: Sulfotransferases	Alcohol sulfotransferase Tyrosylprotein sulfotransferase Aryl sulfotransferase

2.8.3: CoA-transferases	Propionate CoA-transferase

2.8.4: Alkylthio	Coenzyme-B sulfoethylthiotransferase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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Alcohol sulfotransferase

Family members

See also

References

External links