Baboon syndrome

Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), more popularly known as Baboon syndrome because of its resemblance to the distinctive red buttocks displayed by some male baboon species, is a systemic contact dermatitis characterized by well-demarcated patches of erythema distributed symmetrically on the buttocks.[1] The cause of the syndrome may be drug-related, i.e. induced by systemic administration of hydroxyzine[2] penicillin,[3] iodinated radio contrast media[4] and others.

Epidemiology

Baboon syndrome affects both sexes equally, and can occur at any age, but seems to be more common in childhood than in adulthood.[5]

Symptoms and signs

The typical rash commonly appears on buttocks. This then resembles the colour of a baboon’s buttocks. Other areas like upper inner thigh and armpits, may be affected by the rash. The rashes are red and well-defined. The presentation is typically symmetrical and not associated with systemic symptoms.[6]

See also

References

  1. ↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
  2. ↑ Akkari, H.; Belhadjali, H.; Youssef, M.; Mokni, S.; Zili, J. (May 2013). "Baboon syndrome induced by hydroxyzine.". Indian J Dermatol. 58 (3): 244. doi:10.4103/0019-5154.110871. PMID 23723506.
  3. ↑ Handisurya, A.; Stingl, G.; Wöhrl, S. (Apr 2009). "SDRIFE (baboon syndrome) induced by penicillin.". Clin Exp Dermatol. 34 (3): 355–7. doi:10.1111/j.1365-2230.2008.02911.x. PMID 18699835.
  4. ↑ Arnold, AW.; Hausermann, P.; Bach, S.; Bircher, AJ. (2007). "Recurrent flexural exanthema (SDRIFE or baboon syndrome) after administration of two different iodinated radio contrast media.". Dermatology. 214 (1): 89–93. doi:10.1159/000096920. PMID 17191055.
  5. ↑ Moreno-Ramírez, D.; García-Bravo, B.; Pichardo, AR.; Rubio, FP.; Martínez, FC. "Baboon syndrome in childhood: easy to avoid, easy to diagnose, but the problem continues.". Pediatr Dermatol. 21 (3): 250–3. doi:10.1111/j.0736-8046.2004.21313.x. PMID 15165206.
  6. ↑ Utaş, S.; Ferahbaş, A. "Baboon syndrome and segmental vitiligo coexistence.". The Turkish Journal of Pediatrics. 51 (4): 392–4. PMID 19950853.


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