COX7A2L

COX7A2L
Identifiers
Aliases	COX7A2L, COX7AR, COX7RP, EB1, SIG81, cytochrome c oxidase subunit 7A2 like
External IDs	MGI: 106015 HomoloGene: 3463 GeneCards: COX7A2L
Gene ontology Molecular function • electron carrier activity • cytochrome-c oxidase activity Cellular component • mitochondrial inner membrane • membrane • mitochondrion • mitochondrial respiratory chain Biological process • hydrogen ion transmembrane transport • mitochondrial electron transport, cytochrome c to oxygen Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9167	20463
Ensembl	ENSG00000115944	ENSMUSG00000024248
UniProt	O14548	Q61387
RefSeq (mRNA)	NM_004718 NM_001319036 NM_001319037 NM_001319038 NM_001319040	NM_001159529 NM_009187
RefSeq (protein)	NP_004709.2 NP_001305965.1 NP_001305969.1	NP_033213.1
Location (UCSC)	Chr 2: 42.33 – 42.43 Mb	Chr 17: 83.5 – 83.51 Mb
PubMed search	[1]	[2]
Wikidata

Cytochrome c oxidase subunit 7A-related protein, mitochondrial is an enzyme that in humans is encoded by the COX7A2L gene.^[3][4]

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen.^[4]

References

Further reading