CRLF3

CRLF3
Identifiers
Aliases CRLF3, CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2, cytokine receptor like factor 3
External IDs MGI: 1860086 HomoloGene: 9327 GeneCards: CRLF3
Orthologs
Species Human Mouse
Entrez

51379

54394

Ensembl

ENSG00000176390

ENSMUSG00000017561

UniProt

Q8IUI8

Q9Z2L7

RefSeq (mRNA)

NM_015986

NM_001277106
NM_018776

RefSeq (protein)

NP_057070.3

NP_001264035.1
NP_061246.1

Location (UCSC) Chr 17: 30.77 – 30.82 Mb Chr 11: 80.05 – 80.08 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Cytokine receptor-like factor 3 is a protein that in humans is encoded by the CRLF3 gene.[3]

Model organisms

Model organisms have been used in the study of CRLF3 function. A conditional knockout mouse line, called Crlf3tm1a(KOMP)Wtsi[10][11] was generated as part of the International Knockout Mouse Consortium program, a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[12][13][14] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[8][15] Twenty six tests were carried out and two significant phenotypes were reported. Homozygous mutant female adults had a significant increase in circulating levels of fructosamine, while mutants of both sexes had decreased platelet cell numbers.[8]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. "Entrez Gene: cytokine receptor-like factor 3".
  4. "Clinical chemistry data for Crlf3". Wellcome Trust Sanger Institute.
  5. "Haematology data for Crlf3". Wellcome Trust Sanger Institute.
  6. "Salmonella infection data for Crlf3". Wellcome Trust Sanger Institute.
  7. "Citrobacter infection data for Crlf3". Wellcome Trust Sanger Institute.
  8. 1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  9. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  10. "International Knockout Mouse Consortium".
  11. "Mouse Genome Informatics".
  12. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410Freely accessible. PMID 21677750.
  13. Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  14. Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  15. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837Freely accessible. PMID 21722353.

Further reading


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