Cas1
| CRISPR-associated protein 1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | cas1 | ||||||||
| Pfam | PF01867 | ||||||||
| InterPro | IPR002729 | ||||||||
| |||||||||
CRISPR-associated protein 1 (cas1) is one of the two universally conserved proteins found in the CRISPR prokaryotic immune defense system. Cas1 is a metal-dependent DNA-specific endonuclease that produces double-stranded DNA fragments.[1] Cas1 forms a stable complex with the other universally conserved CRISPR-associated protein, cas2, which is essential to spacer acquisition for CRISPR systems.[2]
References
- ↑ Wiedenheft B, Zhou K, Jinek M, Coyle SM, Ma W, Doudna JA (2009). "Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense". Structure. 17 (6): 904–12. doi:10.1016/j.str.2009.03.019. PMID 19523907.
- ↑ Nuñez JK, Kranzusch PJ, Noeske J, Wright AV, Davies CW, Doudna JA (2014). "Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity". Nat. Struct. Mol. Biol. 21 (6): 528–34. doi:10.1038/nsmb.2820. PMC 4075942
. PMID 24793649.
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