Complement receptor of the immunoglobulin family

V-set and immunoglobulin domain containing 4
Identifiers
Symbol VSIG4
Entrez 11326
HUGO 17032
OMIM 300353
RefSeq NM_007268
UniProt Q9Y279
Other data
Locus Chr. X q12-q13.3

Complement receptor of the immunoglobulin family is a protein expressed in Kupffer cells.[1]It is a critical receptor for the phagocytosis of opsonised particles in the blood. It recognizes iC3b (inactivated C3b) deposited on microbial surfaces.

See also

References

  1. Helmy K, Katschke K, Gorgani N, Kljavin N, Elliott J, Diehl L, Scales S, Ghilardi N, van Lookeren Campagne M (2006). "CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens.". Cell. 124 (5): 915–27. doi:10.1016/j.cell.2005.12.039. PMID 16530040.
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