DCBLD2

DCBLD2
Identifiers
Aliases DCBLD2, CLCP1, ESDN, discoidin, CUB and LCCL domain containing 2
External IDs MGI: 1920629 HomoloGene: 12499 GeneCards: DCBLD2
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

131566

73379

Ensembl

ENSG00000057019

ENSMUSG00000035107

UniProt

Q96PD2

Q91ZV3

RefSeq (mRNA)

NM_080927

NM_028523

RefSeq (protein)

NP_563615.3

NP_082799.2

Location (UCSC) Chr 3: 98.8 – 98.9 Mb Chr 16: 58.41 – 58.47 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Discoidin, CUB and LCCL domain-containing protein 2 is a protein that in humans is encoded by the DCBLD2 gene.[3][4]

Model organisms

Model organisms have been used in the study of DCBLD2 function. A conditional knockout mouse line called Dcbld2tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[5] Male and female animals underwent a standardized phenotypic screen[6] to determine the effects of deletion.[7][8][9][10] Additional screens performed: - In-depth immunological phenotyping[11]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Kobuke K, Furukawa Y, Sugai M, Tanigaki K, Ohashi N, Matsumori A, Sasayama S, Honjo T, Tashiro K (Sep 2001). "ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury". The Journal of Biological Chemistry. 276 (36): 34105–14. doi:10.1074/jbc.M105293200. PMID 11447234.
  4. "Entrez Gene: DCBLD2 discoidin, CUB and LCCL domain containing 2".
  5. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  6. 1 2 "International Mouse Phenotyping Consortium".
  7. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410Freely accessible. PMID 21677750.
  8. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  9. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  10. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207Freely accessible. PMID 23870131.
  11. 1 2 "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

  • Sadeghi MM, Esmailzadeh L, Zhang J, Guo X, Asadi A, Krassilnikova S, Fassaei HR, Luo G, Al-Lamki RS, Takahashi T, Tellides G, Bender JR, Rodriguez ER (Sep 2007). "ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis". American Journal of Transplantation. 7 (9): 2098–105. doi:10.1111/j.1600-6143.2007.01919.x. PMID 17697260. 
  • Chen Y, Low TY, Choong LY, Ray RS, Tan YL, Toy W, Lin Q, Ang BK, Wong CH, Lim S, Li B, Hew CL, Sze NS, Druker BJ, Lim YP (Jul 2007). "Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells". Proteomics. 7 (14): 2384–97. doi:10.1002/pmic.200600968. PMID 17570516. 
  • Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM (Sep 2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Molecular & Cellular Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569. 
  • Koshikawa K, Osada H, Kozaki K, Konishi H, Masuda A, Tatematsu Y, Mitsudomi T, Nakao A, Takahashi T (Apr 2002). "Significant up-regulation of a novel gene, CLCP1, in a highly metastatic lung cancer subline as well as in lung cancers in vivo". Oncogene. 21 (18): 2822–8. doi:10.1038/sj.onc.1205405. PMID 11973641. 
  • Nadadur SS, Ehrke MJ, Gurtoo HL (Dec 1999). "A novel TNF-inducible message with putative growth suppressor function". Biochimica et Biophysica Acta. 1489 (2-3): 433–9. doi:10.1016/s0167-4781(99)00189-x. PMID 10673047. 


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