DGKB

DGKB
Identifiers
Aliases	DGKB, DAGK2, DGK, DGK-BETA, diacylglycerol kinase beta
External IDs	MGI: 2442474 HomoloGene: 37875 GeneCards: DGKB
Genetically Related Diseases
type 2 diabetes mellitus, lymphoblastic leukemia[1]
Gene ontology Molecular function • transferase activity • nucleotide binding • calcium ion binding • ATP binding • metal ion binding • kinase activity • diacylglycerol kinase activity Cellular component • cytoplasm • plasma membrane Biological process • platelet activation • protein kinase C-activating G-protein coupled receptor signaling pathway • intracellular signal transduction • phosphorylation • glycerolipid metabolic process • carbohydrate phosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1607	217480
Ensembl	ENSG00000136267	ENSMUSG00000036095
UniProt	Q9Y6T7	Q6NS52
RefSeq (mRNA)	NM_004080 NM_145695	NM_178681
RefSeq (protein)	NP_004071.1 NP_663733.1	NP_848796.2
Location (UCSC)	Chr 7: 14.15 – 14.97 Mb	Chr 12: 37.88 – 38.63 Mb
PubMed search	[2]	[3]
Wikidata

Diacylglycerol kinase beta is an enzyme that in humans is encoded by the DGKB gene.^[4][5]

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene.^[5]

References

Further reading