DIS3L

Identifiers

DIS3L, DIS3L1, DIS3 like exosome 3'-5' exoribonuclease

External IDs

MGI: 2143272 HomoloGene: 15797 GeneCards: DIS3L

Gene ontology
Molecular function	• enzyme binding • nuclease activity • exonuclease activity • protein binding • hydrolase activity • RNA binding • 3'-5'-exoribonuclease activity
Cellular component	• cytoplasmic exosome (RNase complex) • centrosome • plasma membrane • exosome (RNase complex) • cytoplasm • nuclear exosome (RNase complex)
Biological process	• rRNA processing • mRNA catabolic process • RNA phosphodiester bond hydrolysis, exonucleolytic • rRNA catabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


115752


213550

Ensembl


ENSG00000166938


ENSMUSG00000032396

UniProt


Q8TF46


Q8C0S1

RefSeq (mRNA)

NM_001143688 NM_133375 NM_001323936 NM_001323937 NM_001323938
NM_001323939 NM_001323940 NM_001323941 NM_001323943 NM_001323944 NM_001323945 NM_001323946 NM_001323948


NM_001001295 NM_001177784 NM_172519

RefSeq (protein)

NP_001137160.1 NP_588616.1 NP_001310865.1 NP_001310867.1 NP_001310868.1
NP_001310870.1 NP_001310874.1 NP_001310875.1


NP_001001295.2 NP_001171255.1 NP_766107.1

Location (UCSC)

Chr 15: 66.29 – 66.33 Mb

Chr 9: 64.31 – 64.34 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

DIS3-like exonuclease 1 (Dis3L1 or Dis3L) is an enzyme that in humans is encoded by the DIS3L gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the cytoplasm of eukaryotic cells.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Staals RH, Bronkhorst AW, Schilders G, Slomovic S, Schuster G, Heck AJ, Raijmakers R, Pruijn GJ (July 2010). "Dis3-like 1: a novel exoribonuclease associated with the human exosome". EMBO J. 29 (14): 2358–67. doi:10.1038/emboj.2010.122. PMC 2910272. PMID 20531389.
↑ Tomecki R, Kristiansen MS, Lykke-Andersen S, Chlebowski A, Larsen KM, Szczesny RJ, Drazkowska K, Pastula A, Andersen JS, Stepien PP, Dziembowski A, Jensen TH (July 2010). "The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L". EMBO J. 29 (14): 2342–57. doi:10.1038/emboj.2010.121. PMC 2910271. PMID 20531386.

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4: Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease and
ribonuclease)

3.1.11-16: Exonuclease

Exodeoxyribonuclease	RecBCD

Exoribonuclease	Oligonucleotidase

3.1.21-31: Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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