Diclofenac/misoprostol

Diclofenac/misoprostol
Combination of
Diclofenac	NSAID
Misoprostol	Prostaglandin analog
Clinical data
MedlinePlus	a699002
Pregnancy category	Contraindication
Routes of administration	Oral
ATC code	M01AB55 (WHO)
Legal status
Legal status	UK: POM (Prescription only)
Identifiers
(verify)

The combination diclofenac/misoprostol (trade name Arthrotec) is a pharmaceutical product that contains:

Diclofenac sodium: Nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties
Misoprostol: Gastrointestinal (GI) mucosal protective prostaglandin E₁ analog.

In the United Kingdom it is available in two strengths. It is marketed by Pharmacia and its indication is for prophylaxis against NSAID-induced gastroduodenal ulceration in patients requiring diclofenac for rheumatoid arthritis or osteoarthritis.

Arthrotec must not be taken during pregnancy, as it may deform or otherwise harm the fetus, or lead to miscarriage. This may be accompanied by potentially dangerous bleeding, possibly requiring surgery and potentially leading to infertility or death.^[1] As of 2015 the cost for a typical month of medication in the United States is more than 200 USD.^[2]

References

↑ Arthrotec, HealthCentral.com.
↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 7. ISBN 9781284057560.

External links

Access to Summary of Product Characteristics for Diclofenac
Summary of Product Characteristics for Arthrotec 50 from the electronic Medicines Compendium
Patient Information Leaflet for Arthrotec 50 from the electronic Medicines Compendium
Summary of Product Characteristics for Arthrotec 75 from the electronic Medicines Compendium
Patient Information Leaflet for Arthrotec 75 from the electronic Medicines Compendium

Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)

Pyrazolones / Pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡

Salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate

Acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bumadizone Bufexamac Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indomethacin Indomethacin farnesil Isoxepac Ketorolac Lonazolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†

Oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Tenoxicam

Propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ COX-inhibiting nitric oxide donator: Naproxcinod

N-Arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Flufenamic acid Flunixin Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid Flutiazin

Coxibs	Apricoxib Celecoxib Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†

Other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase/Orgotein Tenidap

Items listed in bold indicate initially developed compounds of specific groups. ^#WHO-EM ^†Withdrawn drugs. ^‡Veterinary use medications.

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