ELAVL2

ELAVL2

Identifiers

ELAVL2, HEL-N1, HELN1, HUB, ELAV like neuron-specific RNA binding protein 2

External IDs

MGI: 1100887 HomoloGene: 20930 GeneCards: ELAVL2

Gene ontology
Molecular function	• nucleotide binding • poly(A) RNA binding • protein binding • RNA binding • mRNA 3'-UTR binding • nucleic acid binding
Cellular component	• nucleoplasm
Biological process	• regulation of transcription, DNA-templated • mRNA splicing, via spliceosome
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


1993


15569


ENSG00000107105


ENSMUSG00000008489


Q12926


Q60899

RefSeq (mRNA)


NM_001171195 NM_001171197 NM_004432


NM_001177883 NM_010486 NM_207685 NM_207686

RefSeq (protein)


NP_001164666.1 NP_001164668.1 NP_004423.2


NP_034616.1

Location (UCSC)

Chr 9: 23.69 – 23.83 Mb

Chr 4: 91.25 – 91.4 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

ELAV-like protein 2 is a protein that in humans is encoded by the ELAVL2 gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Han J, Knops JF, Longshore JW, King PH (Feb 1997). "Localization of human elav-like neuronal protein 1 (Hel-N1) on chromosome 9p21 by chromosome microdissection polymerase chain reaction and fluorescence in situ hybridization". Genomics. 36 (1): 189–91. doi:10.1006/geno.1996.0444. PMID 8812435.
↑ "Entrez Gene: ELAVL2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)".

Further reading

Gao FB, Carson CC, Levine T, Keene JD (1994). "Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1.". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 11207–11. doi:10.1073/pnas.91.23.11207. PMC 45196. PMID 7972035.
King PH, Levine TD, Fremeau RT, Keene JD (1994). "Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor.". J. Neurosci. 14 (4): 1943–52. PMID 8158249.
Gao FB, Keene JD (1997). "Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation.". J. Cell. Sci. 109 (3): 579–89. PMID 8907704.
Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA.". Mol. Cell. Biol. 20 (13): 4765–72. doi:10.1128/MCB.20.13.4765-4772.2000. PMC 85909. PMID 10848602.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yano M, Okano HJ, Okano H (2005). "Involvement of Hu and heterogeneous nuclear ribonucleoprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulation.". J. Biol. Chem. 280 (13): 12690–9. doi:10.1074/jbc.M411119200. PMID 15671036.

PDB gallery

1d8z: SOLUTION STRUCTURE OF THE FIRST RNA-BINDING DOMAIN (RBD1) OF HU ANTIGEN C (HUC)

1d9a: SOLUTION STRUCTURE OF THE SECOND RNA-BINDING DOMAIN (RBD2) OF HU ANTIGEN C (HUC)

1fnx: SOLUTION STRUCTURE OF THE HUC RBD1-RBD2 COMPLEXED WITH THE AU-RICH ELEMENT

1fxl: CRYSTAL STRUCTURE OF HUD AND AU-RICH ELEMENT OF THE C-FOS RNA

1g2e: CRYSTAL STRUCTURE OF HUD AND AU-RICH ELEMENT OF THE TUMOR NECROSIS FACTOR ALPHA RNA

This article is issued from Wikipedia - version of the 6/6/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.