EPS8L2

EPS8L2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WWU, 1WXB
Identifiers
Aliases	EPS8L2, EPS8R2, EPS8 like 2
External IDs	MGI: 2138828 HomoloGene: 69358 GeneCards: EPS8L2
Gene ontology Molecular function • Rac guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • actin binding • cadherin binding involved in cell-cell adhesion Cellular component • cytoplasm • ruffle membrane • vesicle • plasma membrane • extracellular exosome • protein complex • cell-cell adherens junction Biological process • regulation of Rho protein signal transduction • Rho protein signal transduction • positive regulation of ruffle assembly • cell-cell adhesion • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64787	98845
Ensembl	ENSG00000177106	ENSMUSG00000025504
UniProt	Q9H6S3	Q99K30
RefSeq (mRNA)	NM_022772	NM_133191
RefSeq (protein)	NP_073609.2	NP_573454.2
Location (UCSC)	Chr 11: 0.69 – 0.73 Mb	Chr 7: 141.34 – 141.36 Mb
PubMed search	[1]	[2]
Wikidata

Epidermal growth factor receptor kinase substrate 8-like protein 2 is an enzyme that in humans is encoded by the EPS8L2 gene.^[3][4]

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown.^[4]

References

Further reading

PDB gallery
1wwu: Solution structure of the SAM_PNT domain of human protein FLJ21935  1wxb: Solution structure of the SH3 domain from human epidermal growth factor receptor pathway substrate 8-like protein