Flosequinan

Flosequinan
Clinical data

ATC code	C01DB01 (WHO)
Identifiers
IUPAC name (RS)-7-fluoro-3-methanesulfinyl-1-methyl-1,4-dihydroquinolin-4-one
CAS Number	76568-02-0^Y
PubChem (CID)	4474062
ChemSpider	3672315^N
UNII	6NB119DLU7^Y
KEGG	D04195^Y
Chemical and physical data
Formula	C₁₁H₁₀FNO₂S
Molar mass	239.267 g/mol
3D model (Jmol)	Interactive image
SMILES CN1C=C(C(=O)C2=C1C=C(C=C2)F)S(=O)C
InChI InChI=1S/C11H10FNO2S/c1-13-6-10(16(2)15)11(14)8-4-3-7(12)5-9(8)13/h3-6H,1-2H3^N Key:UYGONJYYUKVHDD-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Flosequinan is a quinolone vasodilator. It has direct relaxing effects on peripheral arteries and veins. It is administered orally in cases of congestive heart failure in patients who are not responsive to digitalis or ACE inhibitors. It was sold under the trade name Manoplax.

It was withdrawn from the US market in October 1993 due to an increased risk of hospitalization or death.^[1]

References

↑ "Heart drug withdrawn - Boots Pharmaceuticals' Manoplax". FDA Consumer. 1993. Retrieved 2008-12-01.

Vasodilators used in cardiac diseases (C01D)

Nitrovasodilators	Nitroglycerin # Isosorbide dinitrate # Isosorbide mononitrate Itramin tosilate Linsidomine Molsidomine Nicorandil Pentaerythritol tetranitrate Propatylnitrate Tenitramine Trolnitrate

Quinolone vasodilators	Flosequinan^‡

Others	Benziodarone Carbocromen Cinepazet Cloridarol Dilazep Efloxate Etafenone Gapicomine Heptaminol Hexobendine Imolamine Levosimendan Nesiritide Nicorandil Oxyfedrine Pimobendan Prenylamine Serelaxin Trapidil

^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

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