GFI1B

GFI1B

Identifiers

GFI1B, BDPLT17, ZNF163B, growth factor independent 1B transcriptional repressor

External IDs

MGI: 1276578 HomoloGene: 31223 GeneCards: GFI1B

Gene ontology
Molecular function	• DNA binding • protein binding • metal ion binding • RNA polymerase II transcription factor binding • nucleic acid binding
Cellular component	• nuclear matrix • nucleus • transcription factor complex
Biological process	• multicellular organism development • hemopoiesis • regulation of histone H3-K4 methylation • cell proliferation • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription, DNA-templated • covalent chromatin modification
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


8328


14582


ENSG00000165702


ENSMUSG00000026815


Q5VTD9


O70237

RefSeq (mRNA)


NM_001135031 NM_004188


NM_001160406 NM_008114

RefSeq (protein)


NP_001128503.1 NP_004179.3


NP_032140.1

Location (UCSC)

Chr 9: 132.95 – 132.99 Mb

Chr 2: 28.61 – 28.62 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Zinc finger protein Gfi-1b is a protein that in humans is encoded by the GFI1B gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Rodel B, Wagner T, Zornig M, Niessing J, Moroy T (Feb 1999). "The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases". Genomics. 54 (3): 580–2. doi:10.1006/geno.1998.5601. PMID 9878267.
↑ "Entrez Gene: GFI1B growth factor independent 1B (potential regulator of CDKN1A, translocated in CML)".

Further reading

Tong B, Grimes HL, Yang TY, et al. (1998). "The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation.". Mol. Cell. Biol. 18 (5): 2462–73. PMC 110626. PMID 9566867.
Osawa M, Yamaguchi T, Nakamura Y, et al. (2002). "Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis.". Blood. 100 (8): 2769–77. doi:10.1182/blood-2002-01-0182. PMID 12351384.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Huang DY, Kuo YY, Lai JS, et al. (2004). "GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene.". Nucleic Acids Res. 32 (13): 3935–46. doi:10.1093/nar/gkh719. PMC 506805. PMID 15280509.
Garçon L, Lacout C, Svinartchouk F, et al. (2005). "Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells.". Blood. 105 (4): 1448–55. doi:10.1182/blood-2003-11-4068. PMID 15507521.
Huang DY, Kuo YY, Chang ZF (2005). "GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells.". Nucleic Acids Res. 33 (16): 5331–42. doi:10.1093/nar/gki838. PMC 1226314. PMID 16177182.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Xu W, Kee BL (2007). "Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas.". Blood. 109 (10): 4406–14. doi:10.1182/blood-2006-08-043331. PMID 17272506.
Kuo YY, Chang ZF (2007). "GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription.". Mol. Cell. Biol. 27 (12): 4261–72. doi:10.1128/MCB.02212-06. PMC 1900040. PMID 17420275.

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