GSG2

GSG2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2VUW, 2WB8, 3DLZ, 3E7V, 3F2N, 3FMD, 3IQ7, 4OUC, 4QTC, 5HTC, 5HTB

Identifiers

GSG2, HASPIN, germ cell associated 2, haspin

External IDs

MGI: 1194498 HomoloGene: 49236 GeneCards: GSG2

Gene ontology
Molecular function	• transferase activity • nucleotide binding • kinase activity • protein serine/threonine kinase activity • protein binding • histone kinase activity (H3-T3 specific) • ATP binding • protein kinase activity
Cellular component	• cytoplasm • centrosome • chromosome • cytoskeleton • nucleus • spindle
Biological process	• intracellular signal transduction • phosphorylation • histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore • mitotic sister chromatid cohesion • regulation of spindle checkpoint • protein localization to chromosome, centromeric region • cell cycle • protein phosphorylation • covalent chromatin modification
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


83903


14841


ENSG00000177602


ENSMUSG00000050107


Q8TF76


Q9Z0R0

RefSeq (mRNA)


NM_031965


NM_010353

RefSeq (protein)


NP_114171.2


NP_034483.1

Location (UCSC)

Chr 17: 3.72 – 3.73 Mb

Chr 11: 73.14 – 73.14 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Serine/threonine-protein kinase haspin is an enzyme that in humans is encoded by the GSG2 gene.^[3]

References

Further reading

Dai J, Sullivan BA, Higgins JM (2007). "Regulation of mitotic chromosome cohesion by Haspin and Aurora B.". Dev. Cell. 11 (5): 741–50. doi:10.1016/j.devcel.2006.09.018. PMID 17084365.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Dai J, Sultan S, Taylor SS, Higgins JM (2005). "The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment.". Genes Dev. 19 (4): 472–88. doi:10.1101/gad.1267105. PMC 548948. PMID 15681610.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Higgins JM (2001). "The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells.". Gene. 267 (1): 55–69. doi:10.1016/S0378-1119(01)00387-0. PMID 11311556.
Tanaka H, Iguchi N, Nakamura Y, et al. (2001). "Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase.". Mol. Hum. Reprod. 7 (3): 211–8. doi:10.1093/molehr/7.3.211. PMID 11228240.

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