GLYCAM1
| glycosylation dependent cell adhesion molecule-1 | |
|---|---|
| Identifiers | |
| Symbol | GLYCAM1 |
| Entrez | 644076 |
| HUGO | 18023 |
| RefSeq | XM_927461 |
| UniProt | Q8IVK1 |
| Other data | |
| Locus | Chr. 12 q13.2 |
Glycosylation-dependent cell adhesion molecule-1 (GLYCAM1) is a proteoglycan ligand expressed on cells of the high endothelial venules in lymph nodes. It is able to bind to the receptor L-selectin during inflammation, acting as a homing beacon for leukocytes expressing the receptor to enter the site of inflammation.[1] GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin. Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.[2]
External links
- GlyCAM-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
References
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Collins, Tucker. Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X.
- ↑ Dowbenko, D; Kikuta, A; Fennie, C; Gillett, N; Lasky, L A (1993). "Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk.". Journal of Clinical Investigation. 92 (2): 952–60. doi:10.1172/JCI116671. PMC 294935
. PMID 8349827.
This article is issued from Wikipedia - version of the 5/23/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.