HIST1H2BL

HIST1H2BL
Identifiers
Aliases HIST1H2BL, H2B/c, H2BFC, dJ97D16.4, histone cluster 1, H2bl
External IDs MGI: 2448388 HomoloGene: 136771 GeneCards: HIST1H2BL
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

8340

319183

Ensembl

ENSG00000185130

ENSMUSG00000069300

UniProt

Q99880

P10853

RefSeq (mRNA)

NM_003519

NM_178198

RefSeq (protein)

NP_003510.1

Location (UCSC) Chr 6: 27.81 – 27.81 Mb Chr 13: 22.04 – 22.04 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H2B type 1-L is a protein that in humans is encoded by the HIST1H2BL gene.[3][4][5]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656.
  4. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  5. 1 2 "Entrez Gene: HIST1H2BL histone cluster 1, H2bl".

Further reading


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