HLA-Cw7

HLA-Cw7
(MHC Class I, C cell surface antigen)
-
Protein transmembrane receptor/ligand
Structure αβ heterodimer
Subunits HLA-Cw*07--, β2-microglobulin
Older names "-"
-
subtype allele Available structures
Cw7 *0701
- *0702
Alleles link-out to IMGT/HLA database at EBI

HLA-Cw7 (Cw7) is a human leukocyte antigen serotype within HLA-C serotype group. (For more general information on HLA serotypes, please see the article: History and naming of human leukocyte antigens.) Cw7 is determined by the antibody recognition of α7 subset of HLA-Cw α-chains. For the serotype Cw7, the alpha chain are encoded by the HLA-Cw*07 allele group and the β-chain are encoded by B2M locus.[1] Cw7 and Cw*07 are almost synonymous in meaning. Cw7 is more common in West Africa to Ireland. Cw7 in Europe is part of the AH8.1 and HLA B7-DR15-DQ6 haplotypes. The class I region of these supertype is HLA A1-B8 haplotype, HLA A3-B7, HLA-A2-B7 and HLA A24-B7.

Serotype

Cw7 recognition of some HLA Cw*07 gene products[2]
Cw*07 Cw7 Sample
allele % size (N)
*0701 74 304
*0702 68 976

Distribution

HLA Cw*0701 frequencies
Study population Freq.
 (in %)[3]
Cameroon Pygmy Baka 25.0
Ireland South 21.2
German Essen 20.9
Cameroon Sawa 19.2
Ireland Northern 18.7
France West 18.1
Kenya 17.8
Burkina Faso Fulani 17.4
Australia New South Wales 17.3
France South East 17.3
Morocco 'Berber' Nador Me… 16.7
Sudanese 16.5
United Kingdom Caucasians 16.1
Uganda Kampala 16.0
Brazil 15.6
USA Caucasian (2) 15.5
Kenya Nandi 15.2
Pakistan Baloch 15.2
Burkina Faso Rimaibe 14.9
Finland 14.4
Czech Republic 14.2
Swiss Geneva 13.6
South Africa Natal Tamil 13.5
Cameroon Bamileke 13.0
India Khandesh Pawra 13.0
Cameroon Beti 12.9
Tunisia 12.6
India New Delhi 12.5
Saudi Arabia Guraiat and … 12.3
Turkey 12.3
Zambia Lusaka 12.2
Kenya Luo 11.7
Burkina Faso Mossi 11.3
South Korea (1) 11.1
Spain Eastern Andalusia 11.0
USA Hispanic 10.9
Lebanon 10.8
India Tamil Nadu Nadar 10.7
Zimbabwe Harare Shona 10.6
Russia Arkhangelsk Pomors 10.0
Georgia Tibilisi Georgian… 9.8
Mexico Zaptotec Oaxaca 9.7
Israel Arab Druse 9.0
Senegal Niokholo Mandenka 8.7
USA North American Native… 8.6
Pakistan Sindhi 8.3
India North Delhi 8.0
Iran Baloch 7.8
Thailand 7.7
Singapore Riau Malay 7.5
India West Coast Parsis 7.0
Georgia Tibilisi Kurds 6.9
Pakistan Kalash 6.5
Mali Bandiagara 6.2
Pakistan Burusho 5.6
Pakistan Karachi Parsi 5.5
Pakistan Pathan 5.5
Russia Murmansk Saomi 4.0
Singapore Javanese Indone… 4.0
India Mumbai Marathas 3.7
Australia Indig. Cape Yor… 3.4
Pakistan Brahui 3.4
India West Bhils 3.0
China North Han 2.9
Jordan Amman 2.8
China Inner Mongolia 2.5
Italy North Pavia 2.5
Russia Nenets 2.4
China Qinghai Hui 2.3
Australia Indig. Groote E… 2.1
Russia Tuva (2) 2.0
USA Hawaii Okinawa 1.9
USA Asian 1.8
China South Han 1.6
China Beijing 1.5
Papua New Guinea Wanigela 1.4
Allele frequencies presented, only
HLA Cw*0702 frequencies
Study population Freq.
 (in %)[3]
Venezuela Sierra de Perij… 71.4
PNG New Britain Rabaul 57.1
Mexico Mixtec Oaxaca 33.3
China Yunnan Lisu 32.9
Taiwan Taroko 31.8
China Yunnan Nu 30.7
Venezuela Perja Mountain … 30.3
PNG Madang 30.2
Mexico Zaptotec Oaxaca 28.4
Taiwan Tsou 27.5
Mexico Mixe Oaxaca 26.4
Russia Arkhangelsk Pomors 26.0
Ch. Guangdong Meizhou H… 25.8
Pakistan Burusho 25.5
USA South Dakota Lakota S… 24.4
Russia Nenets 23.8
USA New Mexico Canoncito … 23.2
China South Han 20.8
Brazil Terena 20.2
China Guangzhou 19.9
USA Asian 19.5
Ireland Northern 18.6
Swiss Geneva 18.2
Taiwan Bunun 17.8
Ireland South 17.4
Singapore Javanese Indone… 17.0
Philippines Ivatan 16.0
Taiwan Rukai 16.0
Australia New South Wales 15.8
Finland 15.6
USA South Texas Hispanics 15.6
Pakistan Sindhi 15.5
United Kingdom Caucasians 15.5
Saudi Arabia Guraiat and … 15.2
Cameroon Pygmy Baka 15.0
India Tamil Nadu Nadar 14.8
Japan Central 14.6
Russia Murmansk Saomi 14.0
USA Hawaii Okinawa 13.8
China Beijing 13.6
China Tibetan 13.3
China Qinghai Hui 13.2
Thailand 13.0
USA North American Native… 12.8
China Inner Mongolia 12.7
Japan (3) 12.7
Pakistan Brahui 12.5
PNG Wanigela 12.5
USA Caucasian pop2 12.5
USA Hispanic 12.4
Czech Republic 12.3
China North Han 11.9
Taiwan Paiwan 11.8
China Wuhan 11.6
Cameroon Sawa 11.5
Taiwan Siraya 10.8
Taiwan Ami 10.7
New Caledonia 10.0
India North Delhi 9.9
Australia Indig. Cape Yor… 9.6
Pakistan Pathan 9.5
France West 9.4
Iran Baloch 9.4
South Africa Natal Tamil 9.4
German Essen 9.1
Taiwan Puyuma 9.0
India New Delhi 8.9
Pakistan Kalash 8.7
India Mumbai Marathas 8.6
Russia Tuva pop 2 8.6
South Korea (3) 8.3
American Samoa 8.0
Brazil 8.0
USA African American 8.0
France South East 7.2
Cameroon Bamileke 7.1
India West Bhils 7.0
Australia Indig. Yuendumu 6.8
Cameroon Beti 6.6
Georgia Tibilisi Georgian… 6.5
Uganda Kampala 6.1
Turkey 6.0
Spain Eastern Andalusia 5.5
PNG Wosera 5.4
Mali Bandiagara 4.7
Zimbabwe Harare Shona 4.6
Mexico Chihuahua State Ta… 4.5
Pakistan Baloch 4.5
Kenya 4.4
Zambia Lusaka 4.4
Lebanon 4.1
Israel Arab Druse 4.0
Kenya Luo 3.8
Tunisia 3.6
PNG Eastern Highlands Gor… 3.5
Sudanese 3.5
Georgia Tibilisi Kurds 3.4
Morocco 'Berber' Nador Me… 3.2
England London Ashkenazi … 2.9
Allele frequencies presented, only

References

  1. ↑ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
  2. ↑ Allele Query Form IMGT/HLA - European Bioinformatics Institute
  3. 1 2 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
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