2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a

2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a
Names

Other names Photochlor
Identifiers
CAS Number	149402-51-7^N
3D model (Jmol)	Interactive image Interactive image
Abbreviations	HPPH
ChemSpider	4589621^Y
PubChem	5488034
InChI InChI=1S/C39H48N4O4/c1-8-10-11-12-15-47-24(7)36-22(5)30-17-29-21(4)26(13-14-35(45)46)38(42-29)27-16-34(44)37-23(6)31(43-39(27)37)18-32-25(9-2)20(3)28(40-32)19-33(36)41-30/h17-19,21,24,26,40-41H,8-16H2,1-7H3,(H,45,46)/b28-19-,29-17-,30-17-,31-18-,32-18-,33-19-,38-27-/t21-,24?,26-/m0/s1^Y Key: ODJVLHDVEGAIAW-NMWXTPPCSA-N^Y InChI=1/C39H48N4O4/c1-8-10-11-12-15-47-24(7)36-22(5)30-17-29-21(4)26(13-14-35(45)46)38(42-29)27-16-34(44)37-23(6)31(43-39(27)37)18-32-25(9-2)20(3)28(40-32)19-33(36)41-30/h17-19,21,24,26,40-41H,8-16H2,1-7H3,(H,45,46)/b28-19-,29-17-,30-17-,31-18-,32-18-,33-19-,38-27-/t21-,24?,26-/m0/s1 Key: ODJVLHDVEGAIAW-NMWXTPPCBI
SMILES CCCCCCOC(C)C1=C2C=C3C(=C(C(=CC4=NC5=C(CC(=O)C5=C4C)C6=NC(=CC(=C1C)N2)[C@H]([C@@H]6CCC(=O)O)C)N3)CC)C O=C(O)CC[C@@H]6c2nc(cc5c(c(c(cc1c(c(c(n1)cc\3nc4c2CC(=O)\C4=C/3C)CC)C)n5)C(OCCCCCC)C)C)[C@H]6C
Properties
Chemical formula	C₃₉H₄₈N₄O₄
Molar mass	636.84 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references

2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) is a photosensitiser chemical that is used in photodynamic therapy.^[1]

It is being developed under the brand name Photochlor.

Clinical trials

A phase I/II clinical trial started in 1997 for esophageal cancer.^[2]

A phase II trial for non-small cell lung cancer is due to run from 2007 to 2011.^[3]

↑ Lobel, J; MacDonald, IJ; Ciesielski, MJ; Barone, T; Potter, WR; Pollina, J; Plunkett, RJ; Fenstermaker, RA; Dougherty, TJ (2001). "2-1-hexyloxyethyl-2-devinyl pyropheophorbide-a (HPPH) in a nude rat glioma model: implications for photodynamic therapy". Lasers in surgery and medicine. 29 (5): 397–405. doi:10.1002/lsm.10001. PMID 11891727.
↑ Photodynamic Therapy Using HPPH in Treating Patients With Obstructive Esophageal Tumors
↑ Photodynamic Therapy Using HPPH in Treating Patients With Advanced Non-Small Cell Lung Cancer That Blocks the Air Passages

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