Hol-Tox family

The putative holin-like toxin (Hol-Tox) family (TC# 1.E.42) consists of many small proteins, between 34 and 48 amino acyl residues (aas) with a single transmembrane segment (TMSs). Rajesh et al. (2011) first identified the gene and designated it tmp1, which coded for a 34 amino acyl peptide that acts as an antibacterial agent on gram-positive bacteria.[1] This peptide exhibits a single transmembrane domain (TMD) that is believed to play a role in facilitating the antibacterial activity.[1] A representative list of proteins belonging to the Hol-Tox family can be found in the Transporter Classification Database.[2]

See also

Further reading

References

  1. 1 2 Rajesh, Thangamani; Anthony, Thangamani; Saranya, Subramani; Pushpam, Paul Lavanya; Gunasekaran, Paramasamy (2011-02-01). "Functional characterization of a new holin-like antibacterial protein coding gene tmp1 from goat skin surface metagenome". Applied Microbiology and Biotechnology. 89 (4): 1061–1073. doi:10.1007/s00253-010-2907-6. ISSN 1432-0614. PMID 20927512.
  2. "1.E.42 The Putative Holin-like Toxin (Hol-Tox) Family". TCDB. Retrieved 2016-03-28.

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