Indolepyruvate decarboxylase

indolepyruvate decarboxylase
Identifiers
EC number 4.1.1.74
CAS number 9074-92-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an indolepyruvate decarboxylase (EC 4.1.1.74) is an enzyme that catalyzes the chemical reaction

3-(indol-3-yl)pyruvate 2-(indol-3-yl)acetaldehyde + CO2

Hence, this enzyme has one substrate, 3-(indol-3-yl)pyruvate, and two products, 2-(indol-3-yl)acetaldehyde and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]. Other names in common use include indol-3-yl-pyruvate carboxy-lyase, and 3-(indol-3-yl)pyruvate carboxy-lyase. This enzyme participates in tryptophan metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1OVM.

References


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