Jeffrey Karp
| Jeff Karp | |
|---|---|
 Jeffrey Karp | |
| Residence | United States |
| Nationality | Canada |
| Fields | Bioinspired medical problem solver, Tissue adhesives, Biomedical engineering, Mesenchymal stem cell therapy |
| Institutions | Harvard Medical School, Massachusetts Institute of Technology |
| Alma mater | McGill University, University of Toronto, Massachusetts Institute of Technology |
| Doctoral advisor | John Davies & Molly Shoichet |
| Other academic advisors | Robert S. Langer |
| Notable students |
Seungpyo Hong |
Jeff Karp is a Canadian-born world renowned innovator and mentor, known for creating a conducive environment for maximizing the professional development of his trainees and the impact of their discoveries. He is Associate Professor of medicine at Harvard Medical School, Brigham and Women's Hospital. He is principal faculty at the Harvard Stem Cell Institute and Affiliate Faculty at the Massachusetts Institute of Technology through the Harvard–MIT Division of Health Sciences and Technology. He also is an affiliate faculty at the Broad Institute. Karp's strategy is to align with world leading academic collaborators and translators including leading entrepreneurs to maximize scientific rigor and global impact of his highly collaborative approach.
In 2008, MIT's Technology Review listed him as one of the top innovators in the world under the age of 35 (TR35)
In 2014, Karp gave a TEDMED talk and soon after joined the board of advisors at TEDMED.
In 2015, Karp served as a convocation speaker at the University of Toronto for the Faculty of Dentistry and Faculty of Pharmacy.
Prof Karp has given 235 invited lectures, published over 100 papers, trained over 18 people who are now faculty at world leading institutions and many who have leading positions in pharma and biotech, and has filed >70 patent applications (most are licensed and being developed into products). Prof. Karp has co-founded 4 spin-off companies that promise to have a major impact on medicine and currently employ over 40 people. Skintifique has multiple dermatology products on the market targeting patients with sensitive skin (including contact allergies, psoriasis, eczema) that are being sold in pharmacies in Europe and USA and have been used by people in 15 countries via Amazon, Gecko Biomedical is preparing to enter human trials in 2016 with an innovative tissue glue that can seal nearly all tissues throughout the body including sealing holes inside a beating heart - Gecko's products have potential to be used in millions of procedures a year across the globe to augment or replace sutures and staples and enable more minimally invasive procedures to be performed. Frequency Therapeutics harnesses controlled release of small molecules to locally activate stem/progenitor cells in the body to promote regeneration - its lead program targets treatment of chronic hearing loss, where there are no current therapeutic options. Jeff recently started Alivio therapeutics in collaboration with Puretech Health in Boston. The company is based on an inflammation responsive drug delivery system that has already been demonstrated to have efficacy in 6 different disease models.
Education
Jeff was born and raised in Peterborough, Ontario, graduating from Crestwood Secondary School. He graduated from McGill University in 1999 with a degree in chemical engineering.[1] At McGill he was elected to the McGill Senate to represent over 2000 students, he was also a nominated member of the McGill Admissions Committee, the Advisory Committee to Select a new dean of Engineering, and the Student Affairs Senate Sub-Committee. While at McGill he also co-founded the McGill Engineering Code of Ethics "The Blueprint".[2]
He received a Ph.D. in Chemical and Biomedical Engineering from the University of Toronto in 2004.[3] While at the University of Toronto, he was head TA for the Faculty of Engineering, an active member of the Engineering Teaching Committee, and a board member of the Toronto chapter for the Canadian Biomaterials Society. He also actively volunteered on the oncology ward at the Hospital for Sick Children, and worked part-time for MadScience, a hands-on teaching program to spark the imagination and curiosity of elementary students.[4]
From 2004 until 2007, Karp was an NSERC postdoctoral fellow in Robert Langer's laboratory at MIT.[5]
Personal
Karp resides in Brookline, Massachusetts with his wife, two children, and cavalier king charles spaniel (woof).[6]
Research
His research has led to several products on the market, and a number that are under clinical development. His most noticeable work includes bioinspired tissue adhesives to augment or replace sutures and staples,[7][8] engineered stem cell homing,[9][10] cell surface sensors,[11] a needle that automatically stops when it gets to the right location,[6] and inflammation responsive drug release.
Recognition
Karp has published more than 100 peer-reviewed papers and book chapters and has given over 235 national and international invited lectures and has 70 issued or pending patents. Several technologies that he has invented are currently being translated into medical products to improve the quality of life of suffering patients. Dr. Karp's work has been recognized by CNN, NPR Science Fridays, Boston Globe, ABC News, MSNBC, Fox News, CBC Quirks and Quarks, CanadaAM, BBC, LA Times, Forbes, National Geographic, Popular Science, the Washington Post, the New York Post, and by Wired Magazine.
To date, 18 trainees from his laboratory have secured faculty positions at institutions throughout the world.
Among other honors, Karp was elected as a new fellow in the American Institute for Medical and Biological Engineering's (AIMBE) College of Fellows. The College of Fellows is composed of about 1,000 (top 2%) of the country’s most outstanding biomedical and biological engineers in academia, industry, and government. Karp also received the 2011 Young Investigator award from the Society for Biomaterials,[12] and Technology Review listed him in 2008 as one of the top innovators under the age of 35 (TR35).[13]
Karp is a popular mentor in the MIT and Harvard community.[14] He was selected as the Outstanding Faculty Undergraduate Mentor at MIT in 2008 and in 2010 the Harvard-MIT division HST granted him the McMahon Mentoring award as top mentor.[15]
In 2011, the Boston Business Journal profiled him as a Champion in Health Care Innovation.[6]
In 2012, two postdocs from his lab received the prestigious TR35 including Weian Zhao, Bryan Laulicht [16]
In 2013, Karp and his collaborator Dr. Bohdan Pomahac were honored with the Innovative Product of the Year Award from the Institution of Chemical Engineers (IChemE) for their research on worm-inspired microneedle tissue adhesives
In 2014, Karp successfully pitched a 50K microbiome project at the Brigham and Women's Hospital Shark Tank event that was hosted live in Boston by Kevin O'Leary. [17]
In 2014, Maria Nunes Pereira, a graduate student co-advised with Lino Ferreira received the prestigious TR35 [18]
In 2014, Karp presented a talk at TEDMED that shared unexpected insights into the field of bio-inspiration, the art and science of adapting medical tools, treatments, and technologies from solutions found in nature. [19]
In 2015 Karp was recognized by the Boston Business Journal's top 40 under 40, and received the Kenneth Rainin Foundation's Breakthrough Award.
In 2016, his publications collectively reached over 10,800 citations.
Bibliography
Interviews
- Sukel, Kayt (11 October 2014). "From porcupine quills to surgical stitches". New Scientist. 2990: 32–34.
References
- ↑ Houston, Andrea (2008). "Crestwood grad to teach at Harvard; Peterborough native hired to research regenerative medicine, including therapies based on stem cells". The Peterborough Examiner. Retrieved 30 May 2012.
- ↑ http://reporter-archive.mcgill.ca/Rep/r3111/blueprint.html
- ↑ "Jeffrey Karp, PhD". Harvard Stem Cell Institute. Retrieved 28 May 2012.
- ↑ http://www.madscience.org/locations/toronto/
- ↑ http://web.mit.edu/newsoffice/2008/adhesive-0218.html
- 1 2 3 Lowe, Chelsea (August 26, 2011). "Champions in Health Care: Jeffrey Karp, innovator". Boston Business Journal. Retrieved 30 May 2012.
- ↑ Mahdavi, Aborz; et al. (February 19, 2008). "A biodegradable and biocompatible gecko-inspired tissue adhesive". Proceedings of the National Academy of Sciences of the United States of America. 105: 2307–2312. doi:10.1073/pnas.0712117105.
- ↑ "Gecko Toes Inspire Design of New Medical Bandage". WBUR. February 22, 2008. Retrieved 30 May 2012.
- ↑ Karp, Jeffrey M.; Grace Sock; Leng Teo (March 6, 2009). "Mesenchymal Stem Cell Homing: The Devil Is in the Details". Cell Stem Cell. Elsevier. 4 (3): 206–216. doi:10.1016/j.stem.2009.02.001.
- ↑ "Simple Chemical Procedure Augments Therapeutic Potential of Stem Cells". Scientific Frontline. October 31, 2008. Retrieved 30 May 2012.
- ↑ Zhao, Weian; Jeffrey Karp; et al. (July 17, 2011). "Cell-surface sensors for real-time probing of cellular environments". Nature Nanotechnology. Nature Publishing Group. 6: 524–532. doi:10.1038/nnano.2011.101.
- ↑ http://hst.mit.edu/news-and-events/society-biomaterials-young-investigator-award-goes-jeffrey-karp-and-ali
- ↑ "2008 Top 35 Innovators Under 35". Technology Review. 2008. Retrieved August 14, 2011.
- ↑ https://hst.mit.edu/people/faculty/awards/thomas-mcmahon-mentoring-award. Missing or empty
|title=(help) - ↑ http://hst.mit.edu/people/faculty/awards/thomas-mcmahon-mentoring-award
- ↑ http://hst.mit.edu/spotlights/hst-researchers-named-tech-reviews-35-innovators-under-35.
- ↑ http://www.bostonglobe.com/business/2014/06/04/eight-scientists-emerge-from-brigham-and-women-shark-tank-winners/xMCVwdBvszkgPWonHooZfI/story.html
- ↑ http://www.technologyreview.com/lists/innovators-under-35/2014/inventor/maria-nunes-pereira/
- ↑ http://www.tedmed.com/speakers/show?id=309656