John Hardy (geneticist)

John Hardy
Born John Anthony Hardy
(1954-11-09) 9 November 1954
Institutions
Alma mater
Thesis The release of amino acids and phenylethylamine from mammalian synaptosomes (1981)
Notable awards
Website
www.ucl.ac.uk/rlweston-inst/people/john

John Anthony Hardy FRS[1] (born 9 November 1954) is a human geneticist and molecular biologist at the Reta Lila Weston Institute of Neurological Studies at University College London with research interests in neurological diseases.[3][4][5][6]

Education

Hardy received his Bachelor of Science degree from the University of Leeds in 1976[7] and his PhD from Imperial College London in 1981[7] for research on dopamine and amino acid neuropharmacology.

Career and research

Following his PhD, Hardy did postdoctoral research at the MRC Neuropathogenesis Unit in Newcastle upon Tyne, England and then further postdoctoral work at the Swedish Brain Bank in Umeå, Sweden where he started to work on Alzheimer's disease.[7]

He became Assistant Professor of Biochemistry at St. Mary's Hospital, Imperial College London in 1985 and initiated genetic studies of Alzheimer's disease there.[8] He became Associate Professor in 1989 and then took the Pfeiffer Endowed Chair of Alzheimer's Research at the University of South Florida, in Tampa in 1992. In 1996 he moved to Mayo Clinic in Jacksonville, Florida, as Consultant and Professor of Neuroscience.

He became Chair of Neuroscience in 2000 and moved to National Institute on Aging, Bethesda, Maryland, as Chief of the Laboratory of Neurogenetics in 2001. In 2007 he took up the Chair of Molecular Biology of Neurological Disease at the Reta Lila Weston Institute of Neurological Studies, University College London.

On November 29, 2015, he was awarded the Breakthrough Prize.

Patent Misconduct

The United Stated District Court for the Eastern District of Pennsylvania found John Hardy to be an additional inventor on the Swedish mutation patent.[9] Hardy had for years initially denied being an inventor. However, a federal jury found that John Hardy was a co-inventor, and that this omission was deliberately made as “a step in the furtherance of a conspiracy” as Hardy was employed by Imperial College at the time. Hardy stated under oath that he had lied to his employers (Imperial College, UK) at the time about his contribution in order to establish a new career in the United States. British patent law stipulates that such inventions would be owned by the employer and not the employee.[10]

Awards and honours

Among other awards and honours, Hardy has won the Breakthrough Prize in Life Sciences for dissecting the causes of Alzheimer’s disease, Parkinson's disease and frontotemporal dementia; the MetLife prize for research into Alzheimer's disease, and the Potamkin Prize for his work in describing the first genetic mutations in the amyloid gene in Alzheimer's disease, in 1991. He was elected a Fellow of the Royal Society (FRS) in 2009.[1]

References

  1. 1 2 3 4 "Professor John Hardy FMedSci FRS". London: Royal Society. Archived from the original on 2015-11-17.
  2. 1 2 "Professor John Hardy FRS FMedSci".
  3. ↑ HARDY, Prof. John. Who's Who. 2015 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription required)
  4. ↑ Hutton, Mike; Heutink, Peter; Lendon, Corinne L.; Rizzu, Patrizia; Baker, Matt; Froelich, Susanne; Houlden, Henry; Pickering-Brown, Stuart; Chakraverty, Sumi; Isaacs, Adrian; Grover, Andrew; Hackett, Jennifer; Adamson, Jennifer; Lincoln, Sarah; Dickson, Dennis; Davies, Peter; Petersen, Ronald C.; Stevens, Martijn; de Graaff, Esther; Wauters, Erwin; van Baren, Jeltje; Hillebrand, Marcel; Joosse, Marijke; Kwon, Jennifer M.; Nowotny, Petra; Che, Lien Kuei; Norton, Joanne; Morris, John C.; Reed, Lee A.; Trojanowski, John; Basun, Hans; Lannfelt, Lars; Neystat, Michael; Fahn, Stanley; Dark, Francis; Tannenberg, Tony; Dodd, Peter R.; Hayward, Nick; Kwok, John B. J.; Schofield, Peter R.; Andreadis, Athena; Snowden, Julie; Craufurd, David; Neary, David; Owen, Frank; Oostra, Ben A.; Hardy, John; Goate, Alison; van Swieten, John; Mann, David; Lynch, Timothy (1998). "Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17". Nature. 393 (6686): 702–705. doi:10.1038/31508. ISSN 0028-0836. PMID 9641683.
  5. ↑ Goate, Alison; Chartier-Harlin, Marie-Christine; Mullan, Mike; Brown, Jeremy; Crawford, Fiona; Fidani, Liana; Giuffra, Luis; Haynes, Andrew; Irving, Nick; James, Louise; Mant, Rebecca; Newton, Phillippa; Rooke, Karen; Roques, Penelope; Talbot, Chris; Pericak-Vance, Margaret; Roses, Alien; Williamson, Robert; Rossor, Martin; Owen, Mike; Hardy, John (1991). "Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease". Nature. 349 (6311): 704–706. doi:10.1038/349704a0. ISSN 0028-0836.
  6. ↑ Hardy, J. (2002). "The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics". Science. 297 (5580): 353–356. doi:10.1126/science.1072994. ISSN 0036-8075.
  7. 1 2 3 Neuroscience NIH Archived December 10, 2015, at the Wayback Machine.
  8. ↑ HIH.gov Archived November 5, 2011, at the Wayback Machine.
  9. ↑ https://cases.justia.com/federal/district-courts/pennsylvania/paedce/2:2010cv06908/398886/345/0.pdf?ts=1376352919
  10. ↑ UK Patents Act, 1977, c.37
  11. ↑ https://breakthroughprize.org/ Breakthrough Prize 2016
  12. ↑ "The EMBO Pocket Directory" (PDF). European Molecular Biology Organization. Archived from the original on 2015-03-16.
  13. ↑ "EMBO announces new members for 2015". Heidelberg: European Molecular Biology Organization.
  14. ↑ Pritzker, MJ Fox Award for Parkinson Research
  15. ↑ "Dan David Prize: LAUREATES 2014: Combatting Memory Loss, JOHN A. HARDY".
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