John Zhang (scientist)

John Zhang is a medical scientist who made important contributions in fertility research, and particularly in in vitro fertilization.^[1] He made the news headline in September 2016 for successfully producing the world's first three-parent baby using spindle transfer technique.^[2][3] Obtaining an M.D. from Zhejiang University School of Medicine, an M.Sc. from University of Birmingham, and a Ph.D. from University of Cambridge, he became the founder-director of New Hope Fertility Center in New York, USA.^[4]

Biography

John Zhang studied medicine at the Zhejiang University School of Medicine in China. He graduated with an MD in 1984. He continued a post-graduate course at the University of Birmingham, UK. He studied male fertility on which he earned an M.Sc. in 1985. He received the British Postgraduate Scholarship in 1989 with which he pursued further research at the University of Cambridge. He obtained a Ph.D. in 1991 for his thesis on in vitro maturation and fertilization of mammalian oocytes. Between 1991 and 1993, he worked as post-doctoral scholar at Georgetown University in US. From 1993 to 1997, he coordinated a Rockefeller Foundation research programme of Georgetown University with Peking University. He completed residency in the Department of Obstetrics and Gynaecology at the New York University School of Medicine in 1997. He became the first Fellow in the Division of Reproductive Endocrinology and Infertility of New York University School of Medicine in 2001.^[5] In 2004, he founded the New Hope Fertility Center in New York City, becoming its Medical Director. The clinic has been extended to China, Russia, and Mexico.^[6]

Scientific contributions

In 2003, while working with researchers at the Sun Yat-Sen University of Medical Science, Zhang experimented mitochondrial donation technique called pronuclear transfer to help a Chinese mother who had infertility problem. He used a healthy egg cell (ovum) from a donor woman, from which he removed the nucleus. He extracted only the young nuclei (pronuclei) from the mother and her husband, and introduced them into the host egg cell,^[7] hence, the popular name called "three-parent baby". There was about 70% success in fertilization. Five embryos were implanted in the mother's uterus, and she was normally pregnant. He published a preliminary report in 2003 in the journal Fertility and Sterility.^[8] But he was careful of the outcome and did not disclose the full data and results. He was even regretful of breaking the news so soon, blaming his collaborator as "so eager to be famous". As it happened, none of the embryos survived to full term.^[9] He made the full report only after 13 years, in October 2016.^[10]

In order to help a woman (of Jordanian extraction) in Mexico who is having a genetic-neurological trait called Leigh syndrome, Zhang used an another technique called spindle transfer in 2015. Leigh syndrome in the mother is due to mutations in the mitochondrial DNA, and the mother already had four miscarriages, and even the two successful births suffered from the disease and died. Therefore, the only solution to her giving birth to healthy child is to replace the mutant genes with healthy ones. Zhang and his team took out the nucleus from the mother's egg cell and inserted it into a different egg, taken from a donor-woman who has no genetic abnormality, which is already removed of its original nucleus. Thus, the mother's nucleus replaces the nucleus in a donor cell, which has genetically normal mitochondria. The new egg cell was then fertilized with the father's sperm. Zhang could produce only one normally developing embryo out of five he created.^[2] The embryo was then implanted in the mother's uterus, and a healthy boy was born nine month later, on 6 April 2016.^[3] The study was published in the September 2016 issue of Fertility and Sterility.^[11]

Criticisms and comments

Although the baby does not indicate symptoms of the Leigh syndrome, there are still concerns over the genetic conditions. According to the first report, the technique did not completely remove the mother's mitochondria, such that about 1-2% of her faulty mtDNA remained.^[12] However, it is generally considered that less than 20% is too low to cause any problem.^[9]

There are also concerns over the ethical and legal issues. There is an argument that the technique is very close to human cloning, which is generally objected. There is also opposition to nuclear transfer method due to waste of embryos, or potential risk to children born of the technique. The latter point is particularly evidenced by death of the fetuses in China in the earlier experimentation, which made China to ban the technique.^[13] In US, the FDA restricts any mitochondrial transfer techniques in humans, and requires Investigational New Drug application.^[14] (In contrast, UK became the first country to legalized it in 2015.^[15]) However, Zhang chose the clinic branch in Mexico, saying that "there are no rules [there]". And commented that "To save lives is the ethical thing to do."^[16] Sian Harding, member of the British Nuffield Council on Bioethics and the Scientific Advisory Board of the PPP "Stem Cells for Safer Medicines", also defended Zhang that there was no deliberate destruction of embryos, and said, "It's as good as or better than what we'll do in the UK."^[17]

Honours

Zhang is a Founder and Member of the Life Science Society at Cambridge University. He is a Consultant for Reproductive Nuclear Transfer and Stem Cell Research, Cellular Reconstruction and the Special Programme of Therapeutic Cloning at Sun Yat-sen University, Guangzhou; also a Consultant for the IVF and Gamete Laboratory at the Fertility Centre of Wenzhou Medical College, Zhejiang Province, China. He is Member of British Fertility Society, and Member of American Society for Reproductive Medicine (ASRM).^[5]

References