LPCAT1

Identifiers

LPCAT1, lysophosphatidylcholine acyltransferase 1, AYTL2, PFAAP3, lpcat, AGPAT10, AGPAT9

External IDs

Gene ontology
Molecular function	• 1-alkylglycerophosphocholine O-acyltransferase activity • metal ion binding • calcium ion binding • transferase activity • transferase activity, transferring acyl groups • 1-alkylglycerophosphocholine O-acetyltransferase activity • 1-alkenylglycerophosphocholine O-acyltransferase activity • 1-acylglycerophosphocholine O-acyltransferase activity • 1-acylglycerol-3-phosphate O-acyltransferase activity • 2-acylglycerol-3-phosphate O-acyltransferase activity
Cellular component	• integral component of membrane • Golgi apparatus • Golgi membrane • membrane • lipid particle • endoplasmic reticulum membrane • endoplasmic reticulum
Biological process	• phospholipid biosynthetic process • retina development in camera-type eye • lipid metabolic process • phosphatidylglycerol acyl-chain remodeling • positive regulation of protein catabolic process • phosphatidic acid biosynthetic process • triglyceride biosynthetic process • metabolic process • surfactant homeostasis • negative regulation of phosphatidylcholine biosynthetic process • phosphatidylcholine acyl-chain remodeling • phospholipid metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


79888


210992


n/a


ENSMUSG00000021608


Q8NF37


Q3TFD2

RefSeq (mRNA)


NM_024830


NM_145376

RefSeq (protein)


NP_079106.3


NP_663351.3

Location (UCSC)

PubMed search

^[1]

^[2]

Lysophosphatidylcholine acyltransferase 1 is a protein in humans that is encoded by the LPCAT1 gene.^[3]

Lysophosphatidylcholine (LPC) acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: Lysophosphatidylcholine acyltransferase 1".
↑ Nakanishi H, Shindou H, Hishikawa D, Harayama T, Ogasawara R, Suwabe A, Taguchi R, Shimizu T (2006). "Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production". J. Biol. Chem. 281 (29): 20140–7. doi:10.1074/jbc.M600225200. PMID 16704971.

Agonists	C-PAF Edelfosine PAF

Antagonists	A-85783 ABT-491 Apafant BN-50739 BN-52063 Cetirizine CV-3988 CV-6209 Etizolam Ginkgolide B (BN-52021) Israpafant Kadsurenone L-652 Lexipafant Loratadine PCA-4248 Rupatadine SM-12502 SR-27417 SRI 63-441 Terfenadine WEB-2086 Yangambin

Others

Precursors	Choline ATP Phosphocholine PC LPC AAG

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