List of adverse effects of venlafaxine

Incidence of adverse effects^{[1] [2][3]}

The following list shows the rates of adverse symptoms seen in people taking venlafaxine. Many of these effects were seen at rates that were similar or only slightly less in people taking a placebo.

Very common (>10% incidence) adverse effects include:

• Headache — an often transient side effect that is common to most serotonin reuptake inhibitors and that most often occurs at the beginning of therapy or after a dose escalation.
• Nausea — an adverse effect that is more common with venlafaxine than with the SSRIs. Usually transient and less severe in those receiving the extended release formulations.
• Insomnia
• Asthenia (weakness)
• Dizziness
• Ejaculation disorder — sexual side effects can be seen with virtually any antidepressant, especially those that inhibit the reuptake of serotonin (including venlafaxine).^[4]
• Somnolence
• Dry mouth
• Sweating

Common (1–10% incidence) adverse effects include:

Uncommon (0.1-1% incidence) adverse effects include:

Rare (0.01–0.1% incidence) adverse effects include:

• Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
• Thrombocytopenia
• Prolonged bleeding time
• Seizures
• Mania
• Neuroleptic malignant syndrome (NMS)
• Serotonin syndrome
• Akathisia/psychomotor restlessness
• Urinary incontinence

Very rare (<0.01% incidence) adverse effects include:

References