List of full-block structures in New York City

This is a list of full-block structures in New York City:

• 111 Eighth Avenue, a full-block Art Deco multi-use building located between Eighth and Ninth Avenues, and 15th and 16th Streets in the Chelsea neighborhood of the Manhattan borough of New York City
• 731 Lexington Avenue, a 1,400,000 sq ft glass skyscraper on the East Side of Midtown Manhattan, New York City
• Alexander Hamilton U.S. Custom House ,built in 1902–07 by the federal government to house the duty collection operations for the Port of New York
• American Museum of Natural History, one of the largest museums in the world. The museum complex comprises 27 interconnected buildings housing 45 permanent exhibition halls, in addition to a planetarium and a library
• Flatiron Building, a triangular 22-story steel-framed landmarked building located at 175 Fifth Avenue in the borough of Manhattan, New York City
• General Theological Seminary, a seminary of the Episcopal Church located between West 20th and 21st Streets and Ninth and Tenth Avenues in the Chelsea neighborhood of Manhattan
• Museum of Arts and Design
• St. Patrick's Cathedral (Manhattan)
• Starrett-Lehigh Building
• Trump International Hotel and Tower (New York City)
• Tunnel (New York nightclub)
• United Palace
• Waldorf Astoria New York