List of side effects of aripiprazole
The rates of adverse effect effects of aripiprazole is:[1][2][3][4][5]
Adults
Very Common (>10% incidence)
- Weight gain
- Headache
- Agitation
- Insomnia
- Anxiety
- Nausea & vomiting
- Akathisia — a sense of unease and restlessness that presents itself with anxiety
- Lightheadedness
- Constipation
Common (1-10% incidence)
- Dizziness
- Dyspepsia — indigestion
- Somnolence — which is usually mild and transient and less severe than that seen with most antipsychotics.[6]
- Fatigue
- Restlessness
- Dry mouth
- Extrapyramidal side effects (e.g. dystonia, parkinsonism, tremor, etc.)
- Orthostatic hypotension
- Musculoskeletal stiffness
- Abdominal discomfort
- Blurred vision
- Cough
- Pain
- Myalgia
- Rash
- Rhinitis
Uncommon (0.1-1% incidence)
- Leukopenia
- Neutropenia
- Thrombocytopenia
- Bradycardia (low heart rate)
- Palpitations
- Orthostatic hypotension
- Dry eye
- Photophobia
- Diplopia
- Eyelid oedema
- Photopsia
- Diarrhoea
- Gastritis
- pathological gambling[7]
- Dysphagia
- Gastroesophageal reflux disease
- Swollen tongue
- Oesophagitis
- Hypoaesthesia oral
- Face oedema
- Gait disturbance
- Chills
- Discomfort
- Feeling abnormal
- Mobility decreased
- Self-mutilation
- Heart rate increased
- Blood glucose increased
- Pyrexia
- Blood prolactin increased
- Blood urea increased
- Electrocardiogram QT prolonged
- Blood bilirubin increased
- Hepatic enzyme increased
- Increased appetite
- Nocturia
- Polyuria
- Pollakiuria
- Incontinence
- Urinary retention
- Sexual dysfunction
- Amenorrhoea
- Pruritus (itchiness)
- Photosensitivity reaction
- Urticaria
Rare (<0.1%)
- Neuroleptic malignant syndrome (Combination of fever, muscle stiffness, faster breathing, sweating, reduced consciousness, and sudden change in blood pressure and heart rate)
- Suicidal ideation and behaviour
- Depression
- Painful and/or sustained erection (Priapism)
- Seizures
- Rhabdomyolysis
- Agranulocytosis
- Cardiopulmonary failure
- Myocardial infarction (heart attack)
- Atrial flutter
- Supraventricular tachycardia
- Ventricular tachycardia
- Cardio-respiratory arrest
- Atrioventricular block
- Extrasystoles
- Sinus tachycardia
- Atrial fibrillation
- Angina pectoris
- Myocardial ischaemia
- Pancreatitis
- Diabetic ketoacidosis
- Prolonged QT interval (less common than with most other atypical antipsychotic drugs[6])
- Speech disorder
- Electrolyte abnormalities including hyponatraemia, hypokalaemia, hypocalcaemia, etc.
- Thromboembolism
- Hypertension
- Dysphagia
- Oropharyngeal spasm
- Laryngospasm
- Hepatitis
- Jaundice
- Hypersalivation
- Chest pain
- Urinary retention or incontinence
- Alopecia (hair loss)
- Photosensitivity reaction
- Rash
- Xerostomia (when given by injection)
- Tardive dyskinesia (As with all antipsychotic medication, patients using aripiprazole may develop the permanent neurological disorder tardive dyskinesia.[8][9][10])
- Stroke
- Transient Ischaemic Attack
- Increased body temperature
- Angioedema
- Cardiorespiratory arrest
- Cardiorespiratory failure
Sudden unexplained death has been reported, however the frequency is unknown.[11]
Common in children
- Feeling sleepy
- Headache
- Vomiting
- Fatigue
- Increased appetite
- Insomnia
- Nausea
- Stuffy nose
- Weight gain
- Uncontrolled movement such as restlessness, tremor muscle stiffness [7]
References
- ↑ "Product Information for ABILIFYTM Aripiprazole Tablets & Orally Disintegrating Tablets". TGA eBusiness Services. Bristol-Myers Squibb Australia Pty Ltd. 1 November 2012. Retrieved 22 October 2013.
- ↑ "ABILIFY (aripiprazole) tablet ABILIFY (aripiprazole) solution ABILIFY DISCMELT (aripiprazole) tablet, orally disintegrating ABILIFY (aripiprazole) injection, solution [Otsuka America Pharmaceutical, Inc.]". DailyMed. Otsuka America Pharmaceutical, Inc. April 2013. Retrieved 22 October 2013.
- ↑ "Abilify Tablets, Orodispersible Tablets, Oral Solution - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Otsuka Pharmaceuticals (UK) Ltd. 20 September 2013. Retrieved 22 October 2013.
- ↑ "ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS" (PDF). European Medicines Agency. Otsuka Pharmaceutical Europe Ltd. Retrieved 22 October 2013.
- ↑ "Abilify Discmelt, Abilify Maintena (aripiprazole) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 22 October 2013.
- 1 2 Leucht S, Cipriani A, Spineli L, Mavridis D, Orey D, Richter F, Samara M, Barbui C, Engel RR, Geddes JR, Kissling W, Stapf MP, Lässig B, Salanti G, Davis JM (September 2013). "Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis.". Lancet. 382 (9896): 951–962. doi:10.1016/S0140-6736(13)60733-3. PMID 23810019.
- 1 2 "ABILIFY (aripiprazole) [package insert]." (PDF). Otsuka Pharmaceutical Co, Ltd. Retrieved 18 October 2012.
- ↑ Abbasian C, Power P (March 2009). "A case of aripiprazole and tardive dyskinesia". J Psychopharmacol (Oxford). 23 (2): 214–5. doi:10.1177/0269881108089591. PMID 18515468.
- ↑ Zaidi SH, Faruqui RA (January 2008). "Aripiprazole is associated with early onset of Tardive Dyskinesia like presentation in a patient with ABI and psychosis". Brain Inj. 22 (1): 99–102. doi:10.1080/02699050701822493. PMID 18183513.
- ↑ Maytal G, Ostacher M, Stern TA (June 2006). "Aripiprazole-related tardive dyskinesia". CNS Spectr. 11 (6): 435–9. PMID 16816781.
- ↑ http://www.medicines.org.uk/EMC/pdfviewer.aspx?isAttachment=true&documentid=16161
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