MARCH2

MARCH2

Identifiers

MARCH2, MARCH-II, RNF172, HSPC240, membrane associated ring-CH-type finger 2

External IDs

MGI: 1925915 HomoloGene: 9539 GeneCards: MARCH2

Gene ontology
Molecular function	• zinc ion binding • ligase activity • protein binding • metal ion binding • ubiquitin-protein transferase activity
Cellular component	• integral component of membrane • lysosomal membrane • endosome • lysosome • endosome membrane • endoplasmic reticulum membrane • cytoplasmic vesicle • membrane • endoplasmic reticulum
Biological process	• endocytosis • protein ubiquitination
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


51257


224703


ENSG00000099785


ENSMUSG00000079557


Q9P0N8


Q99M02

RefSeq (mRNA)


NM_001005415 NM_001005416 NM_016496


NM_001252480 NM_145486

RefSeq (protein)


NP_001005415.1 NP_001005416.1 NP_057580.3


NP_001239409.1

Location (UCSC)

Chr 19: 8.41 – 8.44 Mb

Chr 17: 33.69 – 33.72 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

E3 ubiquitin-protein ligase MARCH2 is an enzyme that in humans is encoded by the MARCH2 gene.^[3]^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
↑ Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K (Jan 2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". J Virol. 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266.
↑ "Entrez Gene: MARCH2 membrane-associated ring finger (C3HC4) 2".

Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nakamura N, Fukuda H, Kato A, Hirose S (2005). "MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking.". Mol. Biol. Cell. 16 (4): 1696–710. doi:10.1091/mbc.E04-03-0216. PMC 1073653. PMID 15689499.
Fukuda H, Nakamura N, Hirose S (2007). "MARCH-III Is a novel component of endosomes with properties similar to those of MARCH-II.". J. Biochem. 139 (1): 137–45. doi:10.1093/jb/mvj012. PMID 16428329.

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