MPST

MPST
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OLH, 4JGT
Identifiers
Aliases	MPST, MST, TST2, TUM1, mercaptopyruvate sulfurtransferase
External IDs	MGI: 2179733 HomoloGene: 31942 GeneCards: MPST
Gene ontology Molecular function • transferase activity • thiosulfate sulfurtransferase activity • 3-mercaptopyruvate sulfurtransferase activity • identical protein binding Cellular component • cytoplasm • neuron projection • cytosol • cell junction • synapse • extracellular exosome • mitochondrion Biological process • transsulfuration • liver development • cyanate catabolic process • response to toxic substance • kidney development • spinal cord development • hydrogen sulfide biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4357	246221
Ensembl	ENSG00000128309	ENSMUSG00000071711
UniProt	P25325	Q99J99
RefSeq (mRNA)	NM_001013436 NM_001013440 NM_001130517 NM_021126	NM_001162492 NM_001162493 NM_138670
RefSeq (protein)	NP_001013454.1 NP_001123989.1 NP_066949.2	n/a
Location (UCSC)	Chr 22: 37.02 – 37.03 Mb	Chr 15: 78.41 – 78.41 Mb
PubMed search	[1]	[2]
Wikidata

3-mercaptopyruvate sulfurtransferase is an enzyme that in humans is encoded by the MPST gene.^[3][4]

This gene encodes a protein which can function as a monomer or as a disulfide-linked homodimer and which catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cyanide degradation and in thiosulfate biosynthesis. The encoded cytoplasmic protein is a member of the rhodanese family but is not rhodanese itself, which is a mitochondrial protein. Alternatively spliced transcript variants encoding the same protein have been identified.^[4]

References

Further reading