MYBPC1

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
1X44, 2DAV, 2YUV, 2YUW, 2YUX, 2YUZ, 2YXM

Identifiers

Aliases

MYBPC1, LCCS4, MYBPCC, MYBPCS, myosin binding protein C, slow type

External IDs

MGI: 1336213 HomoloGene: 1846 GeneCards: MYBPC1

Gene ontology
Molecular function	• actin binding • structural constituent of muscle • protein binding • titin binding
Cellular component	• myosin filament • cytosol • myofibril
Biological process	• cell adhesion • muscle contraction • positive regulation of protein targeting to mitochondrion • muscle filament sliding
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


4604


109272

Ensembl


ENSG00000196091


ENSMUSG00000020061

UniProt


Q00872


n/a

RefSeq (mRNA)

NM_001254718 NM_001254719 NM_001254720 NM_001254721 NM_001254722
NM_001254723 NM_002465 NM_206819 NM_206820 NM_206821


NM_001252372 NM_175418

RefSeq (protein)

NP_001241647.1 NP_001241648.1 NP_001241649.1 NP_001241650.1 NP_001241651.1
NP_001241652.1 NP_002456.2 NP_996555.1 NP_996556.1 NP_996557.1


n/a

Location (UCSC)

Chr 12: 101.57 – 101.69 Mb

Chr 10: 88.52 – 88.61 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Myosin-binding protein C, slow-type is a protein that in humans is encoded by the MYBPC1 gene.^[3]^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Weber FE, Vaughan KT, Reinach FC, Fischman DA (Oct 1993). "Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment". Eur J Biochem. 216 (2): 661–9. doi:10.1111/j.1432-1033.1993.tb18186.x. PMID 8375400.
↑ Flashman E, Watkins H, Redwood C (Dec 2006). "Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod". Biochem J. 401 (1): 97–102. doi:10.1042/BJ20060500. PMC 1698665. PMID 16918501.
↑ "Entrez Gene: MYBPC1 myosin binding protein C, slow type".

Fürst DO, Vinkemeier U, Weber K (1992). "Mammalian skeletal muscle C-protein: purification from bovine muscle, binding to titin and the characterization of a full-length human cDNA.". J. Cell. Sci. 102 (4): 769–78. PMID 1429890.
Johnston LH, Barker DG, Nurse P (1986). "Cloning and characterization of the Schizosaccharomyces pombe DNA ligase gene CDC17.". Gene. 41 (2–3): 321–5. doi:10.1016/0378-1119(86)90114-9. PMID 3011605.
Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie. 318 (2): 263–72. PMID 7757816.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Alyonycheva TN, Mikawa T, Reinach FC, Fischman DA (1997). "Isoform-specific interaction of the myosin-binding proteins (MyBPs) with skeletal and cardiac myosin is a property of the C-terminal immunoglobulin domain". J. Biol. Chem. 272 (33): 20866–72. doi:10.1074/jbc.272.33.20866. PMID 9252413.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Welikson RE, Fischman DA (2003). "The C-terminal IgI domains of myosin-binding proteins C and H (MyBP-C and MyBP-H) are both necessary and sufficient for the intracellular crosslinking of sarcomeric myosin in transfected non-muscle cells". J. Cell. Sci. 115 (Pt 17): 3517–26. PMID 12154082.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Konno T, Shimizu M, Ino H, et al. (2003). "A novel missense mutation in the myosin binding protein-C gene is responsible for hypertrophic cardiomyopathy with left ventricular dysfunction and dilation in elderly patients". J. Am. Coll. Cardiol. 41 (5): 781–6. doi:10.1016/S0735-1097(02)02957-1. PMID 12628722.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beatham J, Romero R, Townsend SK, et al. (2006). "Filamin C interacts with the muscular dystrophy KY protein and is abnormally distributed in mouse KY deficient muscle fibres". Hum. Mol. Genet. 13 (22): 2863–74. doi:10.1093/hmg/ddh308. PMID 15385448.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Dhoot GK, Perry SV (2006). "Expression of slow skeletal myosin binding C-protein in normal adult mammalian heart". J. Muscle Res. Cell. Motil. 26 (2–3): 143–8. doi:10.1007/s10974-005-3089-1. PMID 16003462.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
McGrath MJ, Cottle DL, Nguyen MA, et al. (2006). "Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly". J. Biol. Chem. 281 (11): 7666–83. doi:10.1074/jbc.M512552200. PMID 16407297.

PDB gallery

1x44: Solution structure of the third ig-like domain of Myosin-dinding protein C, slow-type 2dav: Solution structure of the first ig-like domain of Myosin-binding protein C, slow-type

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MYBPC1

References

Further reading