ONECUT1
| View/Edit Human | View/Edit Mouse |
One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene. [3]
Function
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ "Entrez Gene: One cut homeobox 1". Retrieved 2016-04-13.
Further reading
- Rausa FM, Tan Y, Costa RH (2003). "Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding". Mol. Cell. Biol. 23 (2): 437–49. doi:10.1128/mcb.23.2.437-449.2003. PMC 151533
. PMID 12509444.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This article is issued from Wikipedia - version of the 8/12/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.