PWP2

PWP2

Identifiers

PWP2, EHOC-17, PWP2H, UTP1, PWP2 periodic tryptophan protein homolog (yeast)

External IDs

HomoloGene: 136786 GeneCards: PWP2

Gene ontology
Molecular function	• snoRNA binding • poly(A) RNA binding
Cellular component	• Pwp2p-containing subcomplex of 90S preribosome • nucleus • nucleolus • small-subunit processome • nucleoplasm
Biological process	• ribosomal small subunit assembly • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • rRNA processing
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


5822


n/a


ENSG00000241945


n/a


Q15269


n/a

RefSeq (mRNA)


NM_005049


n/a

RefSeq (protein)


NP_005040.2


n/a

Location (UCSC)

Chr 21: 44.11 – 44.13 Mb

n/a

PubMed search

^[1]

n/a

View/Edit Human

Periodic tryptophan protein 2 homolog is a protein that in humans is encoded by the PWP2 gene.^[2]^[3]

References

↑ "Human PubMed Reference:".
↑ Yamakawa K, Gao DQ, Korenberg JR (Dec 1996). "A periodic tryptophan protein 2 gene homologue (PWP2H) in the candidate region of progressive myoclonus epilepsy on 21q22.3". Cytogenet Cell Genet. 74 (1–2): 140–5. doi:10.1159/000134402. PMID 8893822.
↑ "Entrez Gene: PWP2 PWP2 periodic tryptophan protein homolog (yeast)".

Further reading

Lalioti MD, Chen H, Rossier C, et al. (1996). "Cloning the cDNA of human PWP2, which encodes a protein with WD repeats and maps to 21q22.3". Genomics. 35 (2): 321–7. doi:10.1006/geno.1996.0363. PMID 8661145.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Lafrenière RG, Rochefort DL, Chrétien N, et al. (1997). "Isolation and genomic structure of a human homolog of the yeast periodic tryptophan protein 2 (PWP2) gene mapping to 21q22.3". Genome Res. 6 (12): 1216–26. doi:10.1101/gr.6.12.1216. PMID 8973917.
Nagamine K, Kudoh J, Kawasaki K, et al. (1997). "Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3". Biochem. Biophys. Res. Commun. 235 (1): 185–90. doi:10.1006/bbrc.1997.6758. PMID 9196060.
Nagamine K, Kudoh J, Minoshima S, et al. (1997). "Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21". Genomics. 42 (3): 528–31. doi:10.1006/geno.1997.4761. PMID 9205129.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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