Pemphigoid
| Pemphigoid | |
|---|---|
| Classification and external resources | |
| ICD-10 | L12 |
| ICD-9-CM | 694.5 |
| DiseasesDB | 9760 |
| Patient UK | Pemphigoid |
| MeSH | D010391 |
Pemphigoid is a group of rare autoimmune blistering skin diseases. As its name indicates, pemphigoid is similar in general appearance to pemphigus,[1] but, unlike pemphigus, pemphigoid does not feature acantholysis, a loss of connections between skin cells.[2]
Pemphigoid is more common than pemphigus, and is slightly more common in women than in men. It is also more common in people over 60 years of age than it is in younger people.
Classification
IgG
The forms of pemphigoid are considered to be connective tissue autoimmune skin diseases. There are several types:
- Gestational pemphigoid or Pemphigoid gestationis (PG) (formerly called Herpes gestationis)
- Bullous pemphigoid (BP) Rarely affect the mouth
- Mucous membrane pemphigoid, also known as Cicatricial pemphigoid (CP) (No skin involvement)
Bullous and Cicatricial pemphigoids usually affect persons who are over age 60.[3][4] Gestational pemphigoid occurs during pregnancy,[5] typically in the second or third trimester, and/or immediately following pregnancy.
IgA
Pemphigoid is usually considered to be mediated by IgG, but IgA-mediated forms have also been described.[6]
IgA-mediated immunobullous diseases can often be difficult to treat even with usually effective medications such as rituximab.[7]
See also
References
- ↑ "pemphigoid" at Dorland's Medical Dictionary
- ↑ Pemphigoid at the US National Library of Medicine Medical Subject Headings (MeSH)
- ↑ Cicatricial Pemphigoid at eMedicine
- ↑ Bullous Pemphigoid at eMedicine
- ↑ Pemphigoid Gestationis at eMedicine
- ↑ Thomas T. Provost; John A. Flynn (2001). Cutaneous medicine: cutaneous manifestations of systemic disease. PMPH-USA. pp. 209–. ISBN 978-1-55009-100-7. Retrieved 25 June 2010.
- ↑ He Y, Shimoda M, Ono Y, Villalobos IB, Mitra A, Konia T, Grando SA, Zone JJ, Maverakis E (2015). "Persistence of Autoreactive IgA-Secreting B Cells Despite Multiple Immunosuppressive Medications Including Rituximab". JAMA Dermatol. 151 (6): 646–50. doi:10.1001/jamadermatol.2015.59. PMID 25901938.
External links
- Pemphigoid diseases, Enno Schmidt and Detlef Zillikens, The Lancet, Volume 381, Issue 9863, Pages 320 - 332, 26 January 2013. doi:10.1016/S0140-6736(12)61140-4. The Lancet Seminars.
- Nasal and Oral Mucosal Ulcers, Posted by Sara Fazio, NOW@NEJM, July 19, 2013. Mucous-membrane pemphigoid. [Free]
- The Canadian Pemphigus & Pemphigoid Foundation