Phosducin family

Phosducin (yellow) - Transducin beta-gamma complex
Identifiers
Symbol Phosducin
Pfam PF02114
InterPro IPR001200
SCOP 1b9y
SUPERFAMILY 1b9y
OPM superfamily 139
OPM protein 1b9x

The outer and inner segments of vertebrate retina rod photoreceptor cells contain phosducin, a soluble phosphoprotein that complexes with the beta/gamma-subunits of the guanosine triphosphate-binding protein, transducin. Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of phosducin by protein kinase A.[1] The protein is thought to participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Similar proteins have been isolated from the pineal gland and it is believed that the function of the protein is the same in both retina and pineal gland.[2]

Human proteins containing this domain

Gene Aliases Protein
PDC MEKA phosducin
PDCL PhLP1 phosducin-like
PDCL2 GCPHLP phosducin-like 2
PDCL3 PhLP2A phosducin-like 3
TXNDC9 PhLP3 thioredoxin domain containing 9

References

  1. Craft CM, Lee RH, Fowler A, Lolley RN, McGinnis JF (1990). "Amino acid and cDNA sequence of bovine phosducin, a soluble phosphoprotein from photoreceptor cells". J. Biol. Chem. 265 (26): 15867–15873. PMID 2203790.
  2. Takagi T, Abe T, Nakabayashi H, Tamada H, Sakuragi S, Yamaki K, Shinohara T (1990). "Analysis of the human, bovine and rat 33-kDa proteins and cDNA in retina and pineal gland". Gene. 91 (2): 209–215. doi:10.1016/0378-1119(90)90090-E. PMID 2210381.

This article incorporates text from the public domain Pfam and InterPro IPR001200

This article is issued from Wikipedia - version of the 6/29/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.