Proscillaridin

Proscillaridin
Clinical data

AHFS/Drugs.com	International Drug Names
ATC code	C01AB01 (WHO)
Identifiers
IUPAC name 5-[(3S,8R,9S,10R,13R,14S,17R)-14-Hydroxy- 10,13-dimethyl-3-((2R,3R,4R,5R,6R)-3,4,5-trihydroxy- 6-methyltetrahydro-2H-pyran-2-yloxy)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro- 1H-cyclopenta[a]phenanthren-17-yl]-2H-pyran-2-one
Synonyms	3β-Rhamnosido-14β-hydroxybufa-4,20,22-trienolide
CAS Number	466-06-8^N
PubChem (CID)	5284613
ChemSpider	4447658^Y
UNII	KC6BL281EN^Y
ChEMBL	CHEMBL600325^Y
ECHA InfoCard	100.006.702
Chemical and physical data
Formula	C₃₀H₄₂O₈
Molar mass	530.650
3D model (Jmol)	Interactive image
SMILES O=C\1O\C=C(/C=C/1)[C@H]2CC[C@@]6(O)[C@]2(C)CC[C@H]5[C@H]6CC/C4=C/[C@@H](O[C@@H]3O[C@H]([C@H](O)[C@@H](O)[C@H]3O)C)CC[C@@]45C
InChI InChI=1S/C30H42O8/c1-16-24(32)25(33)26(34)27(37-16)38-19-8-11-28(2)18(14-19)5-6-22-21(28)9-12-29(3)20(10-13-30(22,29)35)17-4-7-23(31)36-15-17/h4,7,14-16,19-22,24-27,32-35H,5-6,8-13H2,1-3H3/t16-,19-,20+,21-,22+,24-,25+,26+,27-,28-,29+,30-/m0/s1^Y Key:MYEJFUXQJGHEQK-ALRJYLEOSA-N^Y
^NY (what is this?) (verify)

Proscillaridin is a cardiac glycoside, a kind of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). It is of the bufanolide type and can be obtained from plants of the genus Scilla and in Drimia maritima (Scilla maritima).^[1]

The aglycone of proscillaridin is scillarenin.

References

↑ Kedra, M.; Kedrowa, S. (1968). "Clinical evaluation of Proscillaridin A, a glycoside of Scilla maritima". Polski tygodnik lekarski (Warsaw, Poland : 1960). 23 (19): 714–716. PMID 4876207.

Bufo	Arenobufagin Bufotalin Cinobufagin Marinobufagin

Scilla	Proscillaridin Scilliroside

Digitalis	Acetyldigitoxin Acetyldigoxin Digitoxin^# Digoxin^# Lanatoside C Deslanoside Metildigoxin Gitoformate

Kalanchoe	Daigremontianin

Strophanthus	Ouabain (g-Strophanthin) k-Strophanthin Cymarin

Thevetia	Peruvoside

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