Protein arginine methyltransferase 5

PRMT5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GQB, 4X60, 4X61, 4X63, 5EML, 5FA5, 5EMJ, 5EMK, 5EMM, 5C9Z
Identifiers
Aliases	PRMT5, HRMT1L5, IBP72, JBP1, SKB1, SKB1Hs, Protein arginine methyltransferase 5
External IDs	MGI: 1351645 HomoloGene: 4454 GeneCards: PRMT5
EC number	2.1.1.125
Gene ontology Molecular function • methyltransferase activity • transferase activity • histone methyltransferase activity (H4-R3 specific) • transcription corepressor activity • protein complex binding • methyl-CpG binding • core promoter sequence-specific DNA binding • protein binding • protein heterodimerization activity • ribonucleoprotein complex binding • histone-arginine N-methyltransferase activity • protein-arginine N-methyltransferase activity • protein-arginine omega-N symmetric methyltransferase activity Cellular component • cytoplasm • cytosol • Golgi apparatus • nucleoplasm • protein complex • methylosome • nucleus • histone methyltransferase complex Biological process • regulation of mitotic nuclear division • positive regulation of oligodendrocyte differentiation • regulation of transcription, DNA-templated • histone H4-R3 methylation • rhythmic process • DNA-templated transcription, termination • negative regulation of cell differentiation • peptidyl-arginine N-methylation • endothelial cell activation • circadian regulation of gene expression • transcription, DNA-templated • spliceosomal snRNP assembly • liver regeneration • methylation • peptidyl-arginine methylation • regulation of ERK1 and ERK2 cascade • regulation of DNA methylation • cell proliferation • Golgi ribbon formation • protein methylation • negative regulation of nucleic acid-templated transcription • positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway • covalent chromatin modification • regulation of signal transduction by p53 class mediator • peptidyl-arginine methylation, to symmetrical-dimethyl arginine Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10419	27374
Ensembl	ENSG00000100462	ENSMUSG00000023110
UniProt	O14744	Q8CIG8
RefSeq (mRNA)	NM_001039619 NM_001282953 NM_001282954 NM_001282955 NM_001282956 NM_006109	NM_013768 NM_001313906 NM_001313907
RefSeq (protein)	NP_001034708.1 NP_001269882.1 NP_001269884.1 NP_001269885.1 NP_006100.2	NP_001300835.1 NP_001300836.1 NP_038796.2
Location (UCSC)	Chr 14: 22.92 – 22.93 Mb	Chr 14: 54.51 – 54.52 Mb
PubMed search	[1]	[2]
Wikidata

Protein arginine N-methyltransferase 5 is an enzyme that in humans is encoded by the PRMT5 gene.^[3][4]

Model organisms

Model organisms have been used in the study of PRMT5 function. A conditional knockout mouse line, called Prmt5^{tm2a(EUCOMM)Wtsi[10][11]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.^[12][13][14]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[8][15] Twenty five tests were carried out on mutant mice and two significant abnormalities were observed.^[8] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice but no further abnormalities were observed.^[8]

Interactions

Protein arginine methyltransferase 5 has been shown to interact with:

• CLNS1A,^[16][17][18]
• Janus kinase 2,^[19]
• SNRPD3,^[18]
• SUPT5H,^[20] and
• WD repeat-containing protein 77.^[16]

References

Further reading