Purple glove syndrome
Purple glove syndrome (PGS) is a poorly understood skin disease in which the extremities become swollen, discoloured and painful.[1] PGS is potentially serious, and may require amputation. PGS is most common among elderly patients and those receiving multiple large intravenous doses of the epilepsy drug phenytoin.[2] Compartment syndrome is a complication of PGS.
Treatment
Doctors recommend discontinuing the use of phenytoin. The application of heat can help to relieve pain. Oral phenytoin can also result in development of purple glove syndrome.[3]
References
- ↑ Chokshi R, Openshaw J, Mehta NN, Mohler E (February 2007). "Purple glove syndrome following intravenous phenytoin administration". Vasc Med. 12 (1): 29–31. doi:10.1177/1358863X07076551. PMID 17451091.
- ↑ O'Brien TJ, Cascino GD, So EL, Hanna DR (October 1998). "Incidence and clinical consequence of the purple glove syndrome in patients receiving intravenous phenytoin". Neurology. 51 (4): 1034–9. doi:10.1212/wnl.51.4.1034. PMID 9781525.
- ↑ http://www.ajemjournal.com/article/S0735-6757%2814%2900407-0/abstract
External links
- FDA: Potential Signals of Serious Risks/New Safety Information Identified by the Adverse Event Reporting System (AERS) -- January - March 2008
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