RuvB-like 1

RUVBL1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2C9O, 2XSZ

Identifiers

Aliases

RUVBL1, ECP54, INO80H, NMP238, PONTIN, Pontin52, RVB1, TIH1, TIP49, TIP49A, ECP-54, NMP 238, RuvB like AAA ATPase 1

External IDs

MGI: 1928760 HomoloGene: 37839 GeneCards: RUVBL1

Gene ontology
Molecular function	• nucleotide binding • ATP-dependent 5'-3' DNA helicase activity • helicase activity • DNA helicase activity • ATPase activity • protein binding • hydrolase activity • ATP binding • cadherin binding involved in cell-cell adhesion
Cellular component	• cytoplasm • Golgi apparatus • membrane • intracellular membrane-bounded organelle • Ino80 complex • nuclear matrix • NuA4 histone acetyltransferase complex • nucleoplasm • microtubule organizing center • MLL1 complex • extracellular exosome • cytoskeleton • nucleus • Swr1 complex • cell-cell adherens junction • R2TP complex
Biological process	• DNA recombination • mitotic nuclear division • regulation of transcription, DNA-templated • positive regulation of protein targeting to mitochondrion • histone H2A acetylation • regulation of transcription from RNA polymerase II promoter • CENP-A containing nucleosome assembly • transcription, DNA-templated • cellular response to DNA damage stimulus • cell division • regulation of mitophagy • spermatogenesis • positive regulation of telomerase RNA localization to Cajal body • histone H4 acetylation • cell cycle • regulation of growth • beta-catenin-TCF complex assembly • cell-cell adhesion • DNA duplex unwinding • box C/D snoRNP assembly • DNA repair • covalent chromatin modification • chromatin remodeling
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


8607


56505

Ensembl


ENSG00000175792


ENSMUSG00000030079

UniProt


Q9Y265


P60122

RefSeq (mRNA)


NM_003707 NM_001319084 NM_001319086


NM_019685

RefSeq (protein)


NP_003698.1 NP_001306013.1


NP_062659.1

Location (UCSC)

Chr 3: 128.06 – 128.15 Mb

Chr 6: 88.47 – 88.5 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

RuvB-like 1 (E. coli), also known as RUVBL1 and TIP49, is a human gene.^[3] RUVBL1 can form a hexamer. The hexamer can form a dodecamer with RUVBL2 protein.^[4] Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.

Interactions

RuvB-like 1 has been shown to interact with:

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: RUVBL1 RuvB-like 1 (E. coli)".
↑ Puri T, Wendler P, Sigala B, Saibil H, Tsaneva IR (February 2007). "Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex". J. Mol. Biol. 366 (1): 179–92. doi:10.1016/j.jmb.2006.11.030. PMID 17157868.
1 2 Park J, Wood MA, Cole MD (March 2002). "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation". Mol. Cell. Biol. 22 (5): 1307–16. doi:10.1128/mcb.22.5.1307-1316.2002. PMC 134713. PMID 11839798.
↑ Bauer A, Huber O, Kemler R (Dec 1998). "Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14787–92. doi:10.1073/pnas.95.25.14787. PMC 24527. PMID 9843967.
1 2 Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM (August 2001). "The p400 complex is an essential E1A transformation target". Cell. 106 (3): 297–307. doi:10.1016/s0092-8674(01)00450-0. PMID 11509179.
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex.". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Kanemaki M, Makino Y, Yoshida T, Kishimoto T, Koga A, Yamamoto K, Yamamoto M, Moncollin V, Egly JM, Muramatsu M, Tamura T (1997). "Molecular cloning of a rat 49-kDa TBP-interacting protein (TIP49) that is highly homologous to the bacterial RuvB". Biochem. Biophys. Res. Commun. 235 (1): 64–8. doi:10.1006/bbrc.1997.6729. PMID 9196036.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Makino Y, Mimori T, Koike C, Kanemaki M, Kurokawa Y, Inoue S, Kishimoto T, Tamura T (1998). "TIP49, homologous to the bacterial DNA helicase RuvB, acts as an autoantigen in human". Biochem. Biophys. Res. Commun. 245 (3): 819–23. doi:10.1006/bbrc.1998.8504. PMID 9588198.
Qiu XB, Lin YL, Thome KC, Pian P, Schlegel BP, Weremowicz S, Parvin JD, Dutta A (1998). "An eukaryotic RuvB-like protein (RUVBL1) essential for growth". J. Biol. Chem. 273 (43): 27786–93. doi:10.1074/jbc.273.43.27786. PMID 9774387.
Holzmann K, Gerner C, Korosec T, Pöltl A, Grimm R, Sauermann G (1998). "Identification and characterization of the ubiquitously occurring nuclear matrix protein NMP 238". Biochem. Biophys. Res. Commun. 252 (1): 39–45. doi:10.1006/bbrc.1998.9604. PMID 9813143.
Bauer A, Huber O, Kemler R (1999). "Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14787–92. doi:10.1073/pnas.95.25.14787. PMC 24527. PMID 9843967.
Kanemaki M, Kurokawa Y, Matsu-ura T, Makino Y, Masani A, Okazaki K, Morishita T, Tamura TA (1999). "TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a". J. Biol. Chem. 274 (32): 22437–44. doi:10.1074/jbc.274.32.22437. PMID 10428817.
Salzer U, Kubicek M, Prohaska R (1999). "Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins". Biochim. Biophys. Acta. 1446 (3): 365–70. doi:10.1016/S0167-4781(99)00104-9. PMID 10524211.
Wood MA, McMahon SB, Cole MD (2000). "An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc". Mol. Cell. 5 (2): 321–30. doi:10.1016/S1097-2765(00)80427-X. PMID 10882073.
Makino Y, Kanemaki M, Koga A, Osano K, Matsu-Ura T, Kurokawa Y, Kishimoto T, Tamura T (2000). "Chromosome mapping and expression of human tip49 family genes". DNA Seq. 11 (1–2): 145–8. doi:10.3109/10425170009033982. PMID 10902922.
Ikura T, Ogryzko VV, Grigoriev M, Groisman R, Wang J, Horikoshi M, Scully R, Qin J, Nakatani Y (2000). "Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis". Cell. 102 (4): 463–73. doi:10.1016/S0092-8674(00)00051-9. PMID 10966108.
Hawley SB, Tamura T, Miles LA (2001). "Purification, cloning, and characterization of a profibrinolytic plasminogen-binding protein, TIP49a". J. Biol. Chem. 276 (1): 179–86. doi:10.1074/jbc.M004919200. PMID 11027681.
Bauer A, Chauvet S, Huber O, Usseglio F, Rothbächer U, Aragnol D, Kemler R, Pradel J (2001). "Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity". EMBO J. 19 (22): 6121–30. doi:10.1093/emboj/19.22.6121. PMC 305835. PMID 11080158.
Park J, Wood MA, Cole MD (2002). "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation". Mol. Cell. Biol. 22 (5): 1307–16. doi:10.1128/MCB.22.5.1307-1316.2002. PMC 134713. PMID 11839798.
Watkins NJ, Dickmanns A, Lührmann R (2003). "Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP". Mol. Cell. Biol. 22 (23): 8342–52. doi:10.1128/MCB.22.23.8342-8352.2002. PMC 134055. PMID 12417735.
Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, Conaway RC, Conaway JW (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.

PDB gallery

2c9o: 3D STRUCTURE OF THE HUMAN RUVB-LIKE HELICASE RUVBL1

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RuvB-like 1

Interactions

References

Further reading