Richard Bonneau
Richard Bonneau is an American computational biologist whose primary research is in the following areas: learning networks from functional genomics data and predicting and designing protein and peptiodomimetic structure. An associate professor at New York University, he holds appointments in the Department of Biology and the Courant Institute of Mathematical Sciences. In 2008, Bonneau was selected as one of the top 20 scientists under 40 by Discover magazine.[1]
In the area of structure prediction, Bonneau was one of the early authors on the Rosetta code, which was one of the first codes to demonstrate the ability to predict protein structure in the absence of sequence homology.[2][3] Using IBM's world community grid to carry out folding of whole proteomes, his group has also applied structure prediction to the problem of genome and proteome annotation.[4][5][6] Bonneau’s laboratory strives to develop new methods that let systems-biologists derive functional forms from relevant biology and parameters from data automatically.
It has made key contributions to the areas of genomics data analysis, focusing on two primary areas: 1. methods for network inference that uncover dynamics and topology from data and 2. methods that learn condition dependent co-regulated groups from integrations of different genomics data-types.[7]
In 2013, he and his colleagues at NYU started a project to examine the impact of social media use on political attitudes and participation by applying methods from a range of academic disciplines. While social media's influence on political participation and attitudes remains in question, Twitter, Facebook, and Instagram undoubtedly offer amounts of data that far exceed earlier research methods. The project-- Social Media and Political Participation (SMaPP) --relies on bothsurvey data and publicly available social media data such as "Tweets"to address a range of questions concerning the causal processes that shape political participation.
Network inference and systems biology
Along with Vestienn Thorsson, David Reiss and Nitin Baliga he developed the Inferelator and cMonkey, two algorithms that were critical to an effort to learn a genome-wide model of the Halobacterium regulatory network. Dr. Nitin Baliga and Dr. Bonneau demonstrated that their model was capable of predicting the genome-wide transcriptional dynamics of the cell’s response to new environments (a work that resulted in publication in Cell in December 2007). This work represents the first fully data driven reconstruction of a cells regulatory network to include learning of kinetic/dynamical parameters as well as network topology.
References
- ↑ “20 Best Brains Under 40,” Discover, December 2008
- ↑ Renfrew PD, Campbell G, Strauss CEM, Bonneau R (2011) The 2010 Rosetta Developers Meeting: Macromolecular Prediction and Design Meets Reproducible Publishing. PLoS ONE 6(8): e22431
- ↑ Renfrew PD, Choi EJ, Bonneau R, Kuhlman B (2012) Incorporation of Noncanonical AminoAcids into Rosetta and Use in Computational Protein-Peptide Interface Design.PLoS ONE 7(3): e32637.
- ↑ Drew K, Winters P, Butterfoss GL, Berstis V, Uplinger K, Armstrong J, Riffle M, Schweighofer E, Bovermann B, Goodlett DR, Davis TN, Shasha D, Malmström L, Bonneau R., Genome Res. 2011 Nov; 21(11):1981-94.
- ↑ The proteome folding project: Proteome-scale prediction of structure and function (2011) Kevin Drew, Patrick Winters, GlennL. Butterfoss, Viktors Berstis, Keith Uplinger, Jonathan Armstrong, MichaelRiffle, Erik Schweighofer, Bill Bovermann, David R. Goodlett, Trisha N. Davis,Dennis Shasha, Lars Malmstrom, and Richard Bonneau. Genome Research, August 8, 2011)
- ↑ Bonneau, R, Facciotti, MT, Reiss, DJ, Madar A, Baliga, NS, et al. A predictive model for transcriptional control of physiology in a free living cell. (2007) Cell. Dec 131:1354-1365
- ↑ Maria Ciofani, Aviv Madar, Carolina Galan, MacLean Sellars, Kieran Mace, Florencia Pauli, Ashish Agarwal, Wendy Huang, Christopher N. Parkurst, Michael Muratet, Kim M. Newberry, Sarah Meadows, Alex Greenfield, Yi Yang, Preti Jain,Francis K. Kirigin, Carmen Birchmeier, Erwin F. Wagner, Kenneth M. Murphy, Richard M. Myers, Richard Bonneau, Dan R. Littman. Cell, October 12, 2012 (Vol. 151, Issue 2, pp. 289-303)
Structure prediction
- Bonneau, R & Baker, D. (2001). Ab Initio Protein Structure Prediction: Progress and Prospects. Annu. Rev. Biophys. Biomol. Struct. 30, 173-89.
- Bonneau, R., Dylan Chivian, Charlie EM Strauss, Carol Rohl, David Baker. (2002) De Novo Prediction of Three Dimensional Structures for Major Protein Families. JMB, 322(1):65-78.
- Bonneau R, Baliga NS, Deutsch EW, Shannon P, Hood L. (2004) Comprehensive de novo structure prediction in a systems-biology context for the archaea Halobacterium sp. NRC-1. Genome Biology. 5(8):R52-68
- Mike Boxem, Zoltan Maliga, Niels J. Klitgord, Na Li, Irma Lemmens, Miyeko Mana, Lorenzo De Lichtervelde, Joram Mul, Diederik van de Peut, Maxime Devos, Nicolas Si-monis, Anne-Lore Schlaitz, Murat Cokol, Muhammed A. Yildirim, Tong Hao, Changyu Fan, Chenwei Lin, Mike Tipsword, Kevin Drew, Matilde Galli, Kahn Rhrissorrakrai, David Drech-sel, David E. Hill, Richard Bonneau, Kristin C. Gunsalus, Frederick P. Roth, Fabio Piano, Jan Tavernier, Sander van den Heuvel, Anthony A. Hyman, Marc Vidal. A Protein Domain-Based Interactome Network for C. elegans Early Embryogenesis. (2008) Cell, 134(3) pp. 534 – 545.
- Andersen-Nissen E, Smith KD, Bonneau R, Strong RK, Aderem A. A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin. (2007) J Exp Med. Feb 19;204(2):393-403.
Genomics and systems biology
- Bonneau, Richard. Learning biological networks: from modules to dynamics. Nature Chemical Biology 4, 658 - 664 (2008)
- Bonneau R, Reiss DJ, Shannon P, Hood L, Baliga NS, Thorsson V (2006) The Inferelator: a procedure for learning parsimonious regulatory networks from systems-biology data-sets de novo. Genome Biol. 7(5):R36.
- David J Reiss, Nitin S Baliga, Bonneau R. (2006) Integrated biclustering of heterogeneous genome-wide datasets. BMC Bioinformatics. 7(1):280.