SFRP2

SFRP2
Identifiers
Aliases	SFRP2, FRP-2, SARP1, SDF-5, secreted frizzled related protein 2
External IDs	MGI: 108078 HomoloGene: 56438 GeneCards: SFRP2
Gene ontology Molecular function • fibronectin binding • receptor agonist activity • G-protein coupled receptor activity • endopeptidase activator activity • integrin binding • Wnt-protein binding • Wnt-activated receptor activity • enzyme activator activity Cellular component • integral component of membrane • extracellular matrix • extracellular fluid • extracellular region Biological process • cellular response to extracellular stimulus • positive regulation of endopeptidase activity • Wnt signaling pathway involved in somitogenesis • somitogenesis • cell differentiation • non-canonical Wnt signaling pathway • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • male gonad development • regulation of establishment of planar polarity • response to nutrient • collagen fibril organization • convergent extension involved in axis elongation • development of primary male sexual characteristics • positive regulation of canonical Wnt signaling pathway • positive regulation of catenin import into nucleus • negative regulation of mesodermal cell fate specification • cellular response to X-ray • cell-cell signaling • negative regulation of Wnt signaling pathway • bone morphogenesis • hematopoietic stem cell proliferation • chondrocyte development • embryonic digit morphogenesis • outflow tract morphogenesis • cardiac left ventricle morphogenesis • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage • Wnt signaling pathway • negative regulation of gene expression • sclerotome development • positive regulation of peptidyl-serine phosphorylation • positive regulation of angiogenesis • planar cell polarity pathway involved in neural tube closure • negative regulation of BMP signaling pathway • multicellular organism development • negative regulation of cardiac muscle cell apoptotic process • regulation of apoptotic process • positive regulation of cell growth • neural tube closure • negative regulation of peptidyl-tyrosine phosphorylation • negative regulation of cell migration • positive regulation of osteoblast differentiation • regulation of Wnt signaling pathway • cartilage development • regulation of cell proliferation • regulation of stem cell division • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • negative regulation of cell growth • neural tube development • positive regulation of cell proliferation • negative regulation of epithelial cell proliferation • positive regulation of apoptotic process • branching involved in blood vessel morphogenesis • post-anal tail morphogenesis • negative regulation of dermatome development • negative regulation of planar cell polarity pathway involved in axis elongation • positive regulation of cell adhesion mediated by integrin • negative regulation of transcription, DNA-templated • negative regulation of JUN kinase activity • positive regulation of fat cell differentiation • negative regulation of epithelial to mesenchymal transition • response to drug • negative regulation of cell proliferation • positive regulation of transcription from RNA polymerase II promoter • digestive tract morphogenesis • anterior/posterior pattern specification • apoptotic process • G-protein coupled receptor signaling pathway • negative regulation of canonical Wnt signaling pathway • regulation of midbrain dopaminergic neuron differentiation • regulation of neuron projection development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6423	20319
Ensembl	ENSG00000145423	ENSMUSG00000027996
UniProt	Q96HF1	P97299
RefSeq (mRNA)	NM_003013	NM_009144
RefSeq (protein)	NP_003004.1	NP_033170.1
Location (UCSC)	Chr 4: 153.78 – 153.79 Mb	Chr 3: 83.77 – 83.77 Mb
PubMed search	[1]	[2]
Wikidata

Secreted frizzled-related protein 2 is a protein that in humans is encoded by the SFRP2 gene.^[3][4]

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.^[4]

References

Further reading