SESN2

SESN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5DJ4, 5CUF
Identifiers
Aliases	SESN2, HI95, SES2, SEST2, sestrin 2
External IDs	MGI: 2651874 HomoloGene: 12873 GeneCards: SESN2
Gene ontology Molecular function • protein binding • oxidoreductase activity, acting on peroxide as acceptor • leucine binding • sulfiredoxin activity • oxidoreductase activity • GDP-dissociation inhibitor activity Cellular component • nucleus • mitochondrion • cytosol • cytoplasm • GATOR2 complex • TORC2 complex • nucleotide-activated protein kinase complex • ATG1/ULK1 kinase complex Biological process • mitochondrial DNA metabolic process • mitochondrion organization • protein kinase B signaling • regulation of cAMP-dependent protein kinase activity • response to insulin • regulation of gluconeogenesis involved in cellular glucose homeostasis • response to glucose • glucose homeostasis • glucose import • regulation of response to reactive oxygen species • triglyceride homeostasis • autophagy • fatty acid beta-oxidation • negative regulation of TORC1 signaling • negative regulation of cell growth • positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress • reactive oxygen species metabolic process • positive regulation of macroautophagy • cellular response to amino acid stimulus • regulation of protein phosphorylation • cellular response to oxidative stress • DNA damage response, signal transduction by p53 class mediator • negative regulation of translation in response to endoplasmic reticulum stress • cellular response to leucine • positive regulation of protein localization to nucleus • cellular oxidant detoxification • oxidation-reduction process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	83667	230784
Ensembl	ENSG00000130766	ENSMUSG00000028893
UniProt	P58004	P58043
RefSeq (mRNA)	NM_031459	NM_144907
RefSeq (protein)	NP_113647.1	NP_659156.1
Location (UCSC)	Chr 1: 28.26 – 28.28 Mb	Chr 4: 132.49 – 132.51 Mb
PubMed search	[1]	[2]
Wikidata

Sestrin-2 also known as Hi95 is a protein that in humans is encoded by the SESN2 gene.^[3][4][5]

Function

This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.^[5][6] The Sestrins constitute a family of evolutionarily-conserved stress-inducible proteins that suppress oxidative stress and regulate adenosine monophosphate-dependent protein kinase (AMPK)- mammalian target of rapamycin (mTOR) signaling. By virtue of these activities, the Sestrins serve as important regulators of metabolic homeostasis. Accordingly, inactivation of Sestrin genes in invertebrates resulted in diverse metabolic pathologies, including oxidative damage, fat accumulation, mitochondrial dysfunction and muscle degeneration that resemble accelerated tissue aging.^[5][7]

See also

• SESN1

References

Further reading