TEP1

TEP1

Identifiers

TEP1, TLP1, TP1, TROVE1, VAULT2, p240, telomerase associated protein 1

External IDs

MGI: 109573 HomoloGene: 5157 GeneCards: TEP1

Gene ontology
Molecular function	• ATP binding • p53 binding • nucleotide binding • enzyme binding • telomerase RNA binding • telomerase activity • RNA binding
Cellular component	• chromosome, telomeric region • telomerase holoenzyme complex • nucleus • cytoplasm • intracellular ribonucleoprotein complex • nuclear matrix • chromosome
Biological process	• telomere maintenance via recombination • RNA-dependent DNA biosynthetic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


7011


21745


ENSG00000129566


ENSMUSG00000006281


Q99973


P97499

RefSeq (mRNA)


NM_007110 NM_001319035


NM_009351

RefSeq (protein)


NP_009041.2


NP_033377.1

Location (UCSC)

Chr 14: 20.37 – 20.41 Mb

Chr 14: 50.82 – 50.87 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Telomerase protein component 1 is an enzyme that in humans is encoded by the TEP1 gene.^[3]^[4]

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans.^[4] It is also a minor vault protein.

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Saito T, Matsuda Y, Suzuki T, Hayashi A, Yuan X, Saito M, Nakayama J, Hori T, Ishikawa F (Jan 1998). "Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases". Genomics. 46 (1): 46–50. doi:10.1006/geno.1997.5005. PMID 9403057.
1 2 "Entrez Gene: TEP1 telomerase-associated protein 1".

Further reading

Joly EC, Tremblay E, Tanguay RM, et al. (1995). "TRiC-P5, a novel TCP1-related protein, is localized in the cytoplasm and in the nuclear matrix". J. Cell. Sci. 107 (10): 2851–9. PMID 7876352.
Harrington L, McPhail T, Mar V, et al. (1997). "A mammalian telomerase-associated protein". Science. 275 (5302): 973–7. doi:10.1126/science.275.5302.973. PMID 9020079.
Harrington L, Zhou W, McPhail T, et al. (1998). "Human telomerase contains evolutionarily conserved catalytic and structural subunits". Genes Dev. 11 (23): 3109–15. doi:10.1101/gad.11.23.3109. PMC 316744. PMID 9389643.
Li H, Zhao L, Yang Z, et al. (1999). "Telomerase is controlled by protein kinase Calpha in human breast cancer cells". J. Biol. Chem. 273 (50): 33436–42. doi:10.1074/jbc.273.50.33436. PMID 9837921.
Kickhoefer VA, Stephen AG, Harrington L, et al. (2000). "Vaults and telomerase share a common subunit, TEP1". J. Biol. Chem. 274 (46): 32712–7. doi:10.1074/jbc.274.46.32712. PMID 10551828.
Li H, Cao Y, Berndt MC, et al. (2000). "Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro". Oncogene. 18 (48): 6785–94. doi:10.1038/sj.onc.1203061. PMID 10597287.
Koyanagi Y, Kobayashi D, Yajima T, et al. (2000). "Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells". Anticancer Res. 20 (2A): 773–8. PMID 10810353.
Beattie TL, Zhou W, Robinson MO, Harrington L (2000). "Polymerization Defects within Human Telomerase Are Distinct from Telomerase RNA and TEP1 Binding". Mol. Biol. Cell. 11 (10): 3329–40. doi:10.1091/mbc.11.10.3329. PMC 14995. PMID 11029039.
Zhang RG, Zhang RP, Wang XW, Xie H (2004). "Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells". Cell Res. 12 (1): 55–62. doi:10.1038/sj.cr.7290110. PMID 11942411.
Chang JT, Chen YL, Yang HT, et al. (2002). "Differential regulation of telomerase activity by six telomerase subunits". Eur. J. Biochem. 269 (14): 3442–50. doi:10.1046/j.1432-1033.2002.03025.x. PMID 12135483.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhou JH, Zhang HM, Chen Q, et al. (2003). "Relationship between telomerase activity and its subunit expression and inhibitory effect of antisense hTR on pancreatic carcinoma". World J. Gastroenterol. 9 (8): 1808–14. PMID 12918126.
Li C, Wu MY, Liang YR, Wu XY (2003). "Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma". World J. Gastroenterol. 9 (11): 2395–9. PMID 14606063.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

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