TUBA4A

TUBA4A
Identifiers
Aliases TUBA4A, H2-ALPHA, TUBA1, ALS22, tubulin alpha 4a
External IDs MGI: 1095410 HomoloGene: 68496 GeneCards: TUBA4A
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

7277

22145

Ensembl

ENSG00000127824

ENSMUSG00000026202

UniProt

P68366

P68368

RefSeq (mRNA)

NM_001278552
NM_006000

NM_009447
NM_001313723
NM_001313724

RefSeq (protein)

NP_001265481.1
NP_005991.1

NP_033473.1

Location (UCSC) Chr 2: 219.25 – 219.28 Mb Chr 1: 75.21 – 75.22 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Tubulin alpha-4A chain is a protein that in humans is encoded by the TUBA4A gene.[3]

Function

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin.[4]

Interactions

TUBA4A has been shown to interact with NCOA6[5] and APC.[6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Villasante A, Wang D, Dobner P, Dolph P, Lewis SA, Cowan NJ (Jul 1986). "Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes". Molecular and Cellular Biology. 6 (7): 2409–19. doi:10.1128/mcb.6.7.2409. PMC 367794Freely accessible. PMID 3785200.
  4. "Entrez Gene: TUBA4A tubulin, alpha 4a".
  5. Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Molecular and Cellular Biology. 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. PMC 140670Freely accessible. PMID 12482968.
  6. Zumbrunn J, Kinoshita K, Hyman AA, Näthke IS (Jan 2001). "Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation". Current Biology. 11 (1): 44–9. doi:10.1016/S0960-9822(01)00002-1. PMID 11166179.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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