Thymopentin

Thymopentin
Clinical data

ATC code	L03AX09 (WHO)
Identifiers
IUPAC name L-arginyl-L-lysyl-L-α-aspartyl-L-valyl-L-tyrosine
Synonyms	(3S)-3-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(2S)-1-hydroxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
PubChem (CID)	451417
ChemSpider	397640^Y
UNII	O3Y80ZF13F^Y
KEGG	D06117^Y
ChEMBL	CHEMBL156025^Y
NIAID ChemDB	000127
Chemical and physical data
Formula	C₃₀H₄₉N₉O₉
Molar mass	679.76496 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(O)cc1)C(C)C)CC(=O)O)CCCCN)[C@@H](N)CCC/N=C(\N)N
InChI InChI=1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)/t19-,20-,21-,22-,24-/m0/s1^Y Key:PSWFFKRAVBDQEG-YGQNSOCVSA-N^Y
(verify)

Thymopentin is an immunostimulant. As such, it has been used in several clinical studies in the early years of the AIDS pandemic (from 1983 to 1985). Thymopentin helped to improve immunological condition in several patients for a brief time under specific treatments.^[1]^[2]^[3]

It interacts with T cells.^[4]

It is a thymic polypeptide.^[5]

References

↑ Mascart-Lemone F, Huygen K, Clumeck N, Brenez D, Bolla K, Duchateau J (1983). "Stimulation of cellular function by thymopentin (TP-5) in three AIDS patients". Lancet. 322 (8352): 735–736. doi:10.1016/S0140-6736(83)92271-7. PMID 6193382.
↑ Clumeck N, Van de Perre P, Mascart-Lemone F, Cran S, Bolla K, Duchateau J (1984). "Preliminary results on clinical and immunological effects of thymopentin in AIDS". Int J Clin Pharmacol Res. 4: 459–463. PMID 6398315.
↑ Clumeck N, Cran S, Van de Perre P, Mascart-Lemone F, Duchateau J, Bolla K (1985). "Thymopentin treatment in AIDS and pre-AIDS patients". Surv Immunol Res. 4 (1): supp1 58–62. PMID 3898293.
↑ Liu Z, Zheng X, Wang J, Wang E (2007). Egli M, ed. "Molecular analysis of thymopentin binding to HLA-DR molecules". PLoS ONE. 2 (12): e1348. doi:10.1371/journal.pone.0001348. PMC 2137936. PMID 18159232.
↑ Peng Y, Chen Z, Yu W, et al. (July 2008). "Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells". Cell Biology International. 32 (10): 1265–71. doi:10.1016/j.cellbi.2008.07.011. PMID 18692582.

Immunostimulants (L03)

Endogenous

Cytokines

Colony-stimulating factors	G-CSF Filgrastim / Pegfilgrastim Lenograstim GM-CSF Molgramostim Sargramostim SCF Ancestim

Interferons	alpha: Albinterferon Interferon alfa natural Interferon alfa 2a / Peginterferon alfa-2a Interferon alfa 2b / Peginterferon alfa-2b Interferon alfa n1 Interferon alfacon-1 Interferon alpha-n3 beta: Interferon beta natural Interferon beta 1a Interferon beta 1b Interferon gamma

Interleukins	Aldesleukin Oprelvekin

Other protein / peptide

Other

Exogenous

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